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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >Accurate 3D temperature dosimetry during hyperthermia therapy by combining invasive measurements and patient-specific simulations
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Accurate 3D temperature dosimetry during hyperthermia therapy by combining invasive measurements and patient-specific simulations

机译：结合侵入性测量和患者特定的模拟，在热疗过程中进行精确的3D温度剂量测定

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Purpose: Dosimetry during deep local hyperthermia treatments in the head and neck currently relies on a limited number of invasively placed temperature sensors. The purpose of this study was to assess the feasibility of 3D dosimetry based on patient-specific temperature simulations and sensory feedback. Materials and methods: The study includes 10 patients with invasive thermometry applied in at least two treatments. Based on their invasive thermometry, we optimised patient-group thermal conductivity and perfusion values for muscle, fat and tumour using a 'leave-one-out' approach. Next, we compared the accuracy of the predicted temperature (Delta T) and the hyperthermia treatment quality (Delta T50) of the optimisations based on the patient-group properties to those based on patient-specific properties, which were optimised using previous treatment measurements. As a robustness check, and to enable comparisons with previous studies, we optimised the parameters not only for an applicator efficiency factor of 40%, but also for 100% efficiency. Results: The accuracy of the predicted temperature (Delta T) improved significantly using patient-specific tissue properties, i.e. 1.0 degrees C (inter-quartile range (IQR) 0.8 degrees C) compared to 1.3 degrees C (IQR 0.7 degrees C) for patient-group averaged tissue properties for 100% applicator efficiency. A similar accuracy was found for optimisations using an applicator efficiency factor of 40%, indicating the robustness of the optimisation method. Moreover, in eight patients with repeated measurements in the target region, Delta T50 significantly improved, i.e. Delta T50 reduced from 0.9 degrees C (IQR 0.8 degrees C) to 0.4 degrees C (IQR 0.5 degrees C) using an applicator efficiency factor of 40%. Conclusion: This study shows that patient-specific temperature simulations combined with tissue property reconstruction from sensory data provides accurate minimally invasive 3D dosimetry during hyperthermia treatments: T50 in sessions without invasive measurements can be predicted with a median accuracy of 0.4 degrees C.
机译：目的：目前在头颈部深部局部热疗期间的剂量测定依赖于数量有限的有创放置的温度传感器。这项研究的目的是根据患者特定的温度模拟和感觉反馈评估3D剂量测定的可行性。材料和方法：该研究包括10例至少在两种治疗中应用侵入性测温法的患者。基于他们的侵入式测温法，我们使用“留一法”方法优化了患者组的肌肉，脂肪和肿瘤的导热系数和灌注值。接下来，我们将基于患者组属性的优化的预测温度（Delta T）和热疗治疗质量（Delta T50）的准确性与基于患者特定属性的优化进行了比较，后者使用先前的治疗方法进行了优化。为了进行鲁棒性检查，并与以前的研究进行比较，我们不仅针对40％的施涂器效率系数，而且针对100％的效率对参数进行了优化。结果：使用患者特定的组织特性，即温度为1.0摄氏度（四分位间距（IQR）0.8摄氏度），而患者的温度为1.3摄氏度（IQR 0.7摄氏度），预测温度（Delta T）的准确性得到了显着提高组平均组织特性可达到100％的涂抹器效率。使用40％的喷头效率系数进行优化时发现了相似的精度，表明优化方法的鲁棒性。此外，在目标区域重复测量的八名患者中，Delta T50显着改善，即使用40％的涂抹器效率系数，Delta T50从0.9摄氏度（IQR 0.8摄氏度）降至0.4摄氏度（IQR 0.5摄氏度）。 。结论：这项研究表明，针对特定患者的温度模拟与根据感官数据进行的组织特性重建相结合，可在热疗期间提供准确的微创3D剂量测定：无创测量的疗程中的T50可以预测为0.4摄氏度的中位准确度。

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