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首页> 外文期刊>International journal of immunogenetics >Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children.
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Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children.

机译：儿童白细胞介素8，CXCR1和CXCR2基因的遗传变异和急性肾盂肾炎的风险。

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Acute pyelonephritis (APN) is the most severe form of urinary tract infection, the etiopathogenesis of which is still not well understood. Previous studies demonstrated that chemotaxis of neutrophils into the tissue and across the infected epithelial layer is a key step in rapid bacterial clearance. Variations within genes encoding the major chemokine interleukin-8 and its receptors CXCR1 and CXCR2 are therefore attractive candidates for participation in genetic predisposition to APN. The aim of our study was to evaluate the association of single nucleotide polymorphisms (SNPs) -251 T/A, +781 C/T, +1633 C/T and +2767 A/T in the IL-8 gene, +2608?G/C in the CXCR1 gene and +1208 C/T in the CXCR2 gene with susceptibility to APN in the Slovak population. PCR-SSP and PCR-RFLP were used to genotype SNPs in 147 children with APN (62 with recurrent and 85 with episodic form) and 215 healthy individuals. Statistical analysis revealed significantly increased frequency of CXCR1 +2608 C allele (P?=?0.0238, OR?=?2.452, 95% CI?=?1.147-5.243) and GC genotype (P?=?0.0201, OR?=?2.627, 95% CI?=?1.188-5.810) and lower frequency of CXCR2 +1208 T allele (P?=?0.0408, OR?=?0.645, 95% CI?=?0.429-0.972) and TT+TC genotypes (P?=?0.0497, OR?=?0.5273, 95% CI?=?0.288-0.964) in patients with recurrent APN compared with healthy controls. Furthermore, the A allele of IL-8 -251 T/A SNP was also significantly overrepresented in patients with recurrent APN when compared with those with only single episode of APN (P?=?0.0439, OR?=?1.627, 95% CI?=?1.019-2.599). Our results indicate that the minor CXCR1 +2608 C allele is associated with significantly increased susceptibility to APN in childhood, while the CXCR2 +1208 T allele confers protection from recurrent APN. Moreover, allele A of the IL-8 -251 T/A may also increase the risk of developing recurrent attacks after the first-time APN.
机译：急性肾盂肾炎（APN）是最严重的泌尿道感染形式，其病因尚未得到很好的了解。先前的研究表明，嗜中性粒细胞趋化性进入组织并跨过感染的上皮层是快速清除细菌的关键步骤。因此，编码主要趋化因子白细胞介素8及其受体CXCR1和CXCR2的基因内的变异是参与APN遗传易感性的诱人候选物。我们研究的目的是评估IL-8基因+2608中的-251 T / A，+ 781 C / T，+ 1633 C / T和+2767 A / T的单核苷酸多态性（SNP）的关联。 CXCR1基因的G / C和CXCR2基因的+1208 C / T对斯洛伐克人口的APN易感。应用PCR-SSP和PCR-RFLP对147名APN患儿（62例复发性和85例发作性）和215名健康个体的SNP进行基因分型。统计分析表明，CXCR1 +2608 C等位基因（P≥= 0.0238，OR≥= 2.452，95％CI≥= 1.147-5.243）和GC基因型（P≥= 0.0201，OR≥= 2.627）的频率显着增加。 ，95％CI？=？1.188-5.810）和较低频率的CXCR2 +1208 T等位基因（P？=？0.0408，OR？=？0.645，95％CI？=？0.429-0.972）和TT + TC基因型（P与健康对照组相比，患有复发性APN的患者的α=？0.0497，OR？=？0.5273，95％CI？=？0.288-0.964）。此外，与仅单次APN发作的患者相比，复发APN的患者中IL-8 -251 T / A SNP的A等位基因也明显过高（P <= 0.0439，OR == 1.627，CI为95％） ？=？1.019-2.599）。我们的研究结果表明，较小的CXCR1 +2608 C等位基因与儿童期对APN的易感性显着增加有关，而CXCR2 +1208 T等位基因可防止复发性APN。此外，IL-8 -251 T / A的等位基因A也可能增加首次APN后复发发作的风险。

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