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首页> 外文期刊>International journal of immunogenetics >A biased Gm haplotype and Gm paraprotein allotype in multiple myeloma suggests a role for the Gm system in myeloma development.
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A biased Gm haplotype and Gm paraprotein allotype in multiple myeloma suggests a role for the Gm system in myeloma development.

机译：多发性骨髓瘤中有偏向的Gm单倍型和Gm副蛋白同种异型暗示了Gm系统在骨髓瘤发展中的作用。

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The association between a particular Gm haplotype and susceptibility to multiple myeloma (MM) is not clear. The reason is probably because no investigations have so far been carried out on the relationship between the Gm haplotype, which represents the inherited combination of IgG Gm allotypes, and the Gm allotype expressed at the IgG paraprotein (M-component), which reflects the enhanced gene expression within the haplotype in MM. We studied the incidence of Gm allotypic markers present in IgG subclasses in the serum from 52 patients with MM and in parallel with the isolated IgG paraproteins. The results showed that 84.6% of the patients were heterozygous for haplotypes Gm(a; z; n-; g;)/Gm(f; n+-; b1; b0; b5) and 15.3% were homozygous for Gm(f; n-; b1; b0; b5), while no homozygous Gm(a; z; n-; g) individuals were found among the studied patients. The incidence of these combinations in the healthy population in Serbia is 34%, 66% and < 1%, respectively. Subjects with Gm(a; z; n-; g)/Gm(f; n+-; b1; b0; b5) combination are over 10 times [odds ratio (OR) 10.69; 95% confidence interval 1.67-68] as likely to be affected by the disease as the subjects with homozygous Gm(f; n+-; b1; b0; b5) combination (OR = 0.35, 95% confidence interval 0.06-2.23). However, despite the Gm heterozygosity, most of the Gm(a; z; n-; g;)/Gm(f; n+-; b1; b0; b5) positive patients with MM (86.3%) had IgG paraprotein with the allotypic marker from the Gm(f; n+-; b1; b0; b5) haplotype. Together with patients homozygous for this haplotype, the relative number of patients with serum IgG paraprotein carrying allotypic marker from the Gm(f; n-; b1; b0; b5) haplotype was 88.5%. These results suggest that the development of an M-component could be related to a disturbance on chromosome 14q32 carrying the Gm (f; n+-; b1; b0; b5) set of genes.
机译：特定的Gm单倍型与多发性骨髓瘤（MM）易感性之间的关联尚不清楚。原因可能是因为到目前为止，尚未对代表IgG Gm同种异型的遗传组合的Gm单倍型与IgG副蛋白（M成分）表达的Gm同种型之间的关系进行任何研究，这反映了增强的MM单倍型内的基因表达。我们研究了52例MM患者血清中IgG亚类中Gm同种异型标记的发生率，并与分离的IgG副蛋白同时发生。结果显示84.6％的患者单倍型Gm（a; z; n-; g;）/ Gm（f; n + / n-; b1; b0; b5）为纯合子，15.3％为Gm（f ; n / n-; b1; b0; b5），而在研究的患者中未发现纯合子Gm（a; z; n-; g）。这些组合在塞尔维亚健康人群中的发生率分别为34％，66％和<1％。具有Gm（a; z; n-; g）/ Gm（f; n + / n-; b1; b0; b5）组合的受试者超过10倍[几率（OR）10.69; 95％置信区间1.67-68]与纯合Gm（f; n + / n-; b1; b0; b5）组合的受试者受疾病影响的可能性相同（OR = 0.35，95％置信区间0.06-2.23） 。然而，尽管存在Gm杂合性，但大多数Gm（a; z; n-; g;）/ Gm（f; n + / n-; b1; b0; b5）阳性的MM患者（86.3％）的IgG副蛋白Gm（f; n + / n-; b1; b0; b5）单倍型的同种异型标记。与该单倍型纯合的患者一起，携带来自Gm（f; n / n-; b1; b0; b5）单倍型的具有同种异型标记的血清IgG副蛋白的患者相对数量为88.5％。这些结果表明，M组分的发育可能与携带Gm（f; n + / n-; b1; b0; b5）基因集的染色体14q32受到干扰有关。

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