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首页> 外文期刊>Biochemical Genetics >A decreasing gradient of 374F allele frequencies in the skin pigmentation gene SLC45A2, from the north of West Europe to North Africa.
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A decreasing gradient of 374F allele frequencies in the skin pigmentation gene SLC45A2, from the north of West Europe to North Africa.

机译：从西欧北部到北非，皮肤色素沉着基因SLC45A2中374F等位基因频率的下降梯度。

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摘要

The 374F mutation in the SLC45A2 gene, encoding the membrane-associated transporter protein (MATP) that plays an important role in melanin synthesis, has been suggested to be associated with skin color in Caucasians. In this study, the detailed distribution of the 374F allele has been investigated in 2063 unrelated subjects from 18 European and three North African populations. The highest allele frequency is observed in Denmark (0.980), and the lowest frequencies are observed in Tunisia (0.610) and in Morocco (0.691). A significant latitudinal cline in 374F allele frequencies was observed, ranging from the north of West Europe to North Africa (r = 0.869). The results confirm that the distribution of the 374F allele may reflect the ultraviolet radiation level and can be associated with skin color variation in these regions.
机译：SLC45A2基因中的374F突变编码与膜相关的转运蛋白（MATP）在黑色素合成中起重要作用，已被认为与白种人的肤色有关。在这项研究中，已经对来自18个欧洲和三个北非人群的2063个无关的受试者进行了374F等位基因的详细分布研究。在丹麦（0.980）观察到最高等位基因频率，在突尼斯（0.610）和摩洛哥（0.691）观察到最低频率。从西欧北部到北非，观察到374F等位基因频率存在明显的纬度谱系（r = 0.869）。结果证实，374F等位基因的分布可能反映了紫外线辐射水平，并且可能与这些区域的肤色变化有关。

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