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首页> 外文期刊>International journal of immunogenetics >Distribution of HLA-G 14-bp insertion/deletion polymorphism in six Chinese ethnic groups.
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Distribution of HLA-G 14-bp insertion/deletion polymorphism in six Chinese ethnic groups.

机译：HLA-G 14 bp插入/缺失多态性在六个中国民族中的分布。

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摘要

Recently, a 14-bp insertion/deletion polymorphism (+14?bp/-14?bp) in exon 8 of the Human leucocyte antigen-G (HLA-G) gene has been studied extensively because this polymorphism has been associated with HLA-G mRNA stability and could influence HLA-G mRNA expression. We investigated the distribution of the 14-bp insertion/deletion polymorphism in six different Chinese ethnic groups (Bulang, Wa, Hani, Jinuo, Maonan and Zhuang), which originated from three major ancient tribes (Di-Qiang, Baipu and Baiyue) in China. Comparison of the 14-bp insertion frequency in the six groups with other Chinese groups showed marked variation among the three ancient tribes, Di-Qing (0.490-0.534), Baipu (0.470-0.609) and Baiyue (0.280-0.344). Furthermore, the frequencies of the 14-bp insertion were similar in groups that came from the same ancient tribe, which indicated that the individuals who share the 14-bp insertion have the most probably inherited the 14-bp element from a common ancestor. In addition, an intra-tribal comparison of the 14-bp insertion/deletion frequencies between the descendants of the ancient ancestral tribes suggests that population histories or some environmental effects, such as founder effect or isolation, might also influence the distribution.
机译：最近，由于人类白细胞抗原-G（HLA-G）基因第8外显子的14-bp插入/缺失多态性（+14？bp / -14？bp），已得到广泛研究，因为该多态性与HLA- G mRNA的稳定性，并可能影响HLA-G mRNA的表达。我们调查了起源于三个主要古代部落（狄强，白埔和白月）的六个中国民族（布琅，Wa族，哈尼族，基诺族，毛南族和壮族）14 bp插入/缺失多态性的分布。中国。六个族群与其他中国族群的14-bp插入频率的比较显示，三个古代部落之间的差异显着：狄青（0.490-0.534），白蒲（0.470-0.609）和白月（0.280-0.344）。此外，来自同一古老部落的群体中14 bp插入的频率相似，这表明共享14 bp插入的个体最有可能从共同祖先那里遗传了14 bp元素。此外，部落内部对古代祖先部落后代之间14 bp插入/删除频率的比较表明，人口历史或某些环境影响（如奠基人的影响或孤立）也可能影响分布。

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