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首页> 外文期刊>International journal of immunogenetics >Nucleotide sequence and polymorphism of MHC class II DQB exon 2 alleles in Chinese yakow (Bos grunniens × Bos taurus)
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Nucleotide sequence and polymorphism of MHC class II DQB exon 2 alleles in Chinese yakow (Bos grunniens × Bos taurus)

机译：中国ak牛MHC II类DQB外显子2等位基因的核苷酸序列和多态性（Bos grunniens×Bos taurus）

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摘要

Summary: The objective of this study is to describe the gene characteristics of the bovine lymphocyte antigen (BoLA)-DQB exon 2 locus in Chinese yakow (Bos grunniens × Bos taurus) and to compare it with previously reported patterns in other bovidae species to investigate genetic factors for disease resistance. The exon 2 of the MHC class II DQB gene was cloned and sequenced. It was revealed by sequence analyses that there are 36 DQB exon 2 alleles among 44 Chinese yakow. These alleles exhibited a high degree of nucleotide and amino acid polymorphism with most amino acid variations occurring at positions forming the peptide-binding sites (PBS). The DQB loci were analysed for patterns of synonymous (dS) and nonsynonymous (dN) substitution. The Chinese yakow was observed to be under strong positive selection in the DQB exon 2 peptide-binding sites (dN = 0.147, P 0.01). It appears that this variability among Chinese yakow confers the ability to mount immune responses to a wide variety of peptides or pathogens.
机译：摘要：本研究的目的是描述中国Chinese牛（Bos grunniens×Bos taurus）牛淋巴细胞抗原（BoLA）-DQB外显子2基因座的基因特征，并将其与先前报道的其他牛科物种的模式进行比较抗病的遗传因素。 MHC II类DQB基因的外显子2被克隆并测序。通过序列分析发现，在44个中国牛中有36个DQB外显子2等位基因。这些等位基因表现出高度的核苷酸和氨基酸多态性，其中大多数氨基酸变异发生在形成肽结合位点（PBS）的位置。分析了DQB位点的同义（dS）和非同义（dN）替换模式。观察到中国牛在DQB外显子2肽结合位点处于强阳性选择下（dN = 0.147，P <0.01）。看来中国Chinese牛的这种变异性赋予了对多种肽或病原体发起免疫反应的能力。

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