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首页> 外文期刊>International journal of immunogenetics >Transforming growth factor beta receptor II (TGFBR2) polymorphisms and the association with nonsegmental vitiligo in the Korean population.
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Transforming growth factor beta receptor II (TGFBR2) polymorphisms and the association with nonsegmental vitiligo in the Korean population.

机译：转化生长因子β受体II（TGFBR2）多态性和与韩国人群中非段白癜风的关联。

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摘要

The precise cause of vitiligo is unknown. However, autoimmunity is considered the most likely aetiology, especially in nonsegmental vitiligo (NSV). In this study we determined whether or not the transforming growth factor beta receptor II (TGFBR2) gene contributes to susceptibility for NSV in the Korean population. Blood samples were collected from 415 controls and 233 cases. We selected three single nucleotide polymorphisms (SNPs) in the TGFBR2 gene. The genotypes of the SNPs were determined using direct sequencing. All of the SNPs were significantly different between the vitiligo patients and controls (rs2005061, co-dominant, dominant, recessive, P < 0.05; rs3773645, co-dominant, dominant, recessive, P < 0.05; rs3773649, co-dominant, recessive, P < 0.05). In addition, haplotype 1 (CG) and haplotype 2 (GA) of the linkage disequilibrium (LD) block were also associated with a risk of NSV. The present study suggests that TGFBR2 might be related to NSV.
机译：白癜风的确切原因尚不清楚。但是，自身免疫被认为是最可能的病因，尤其是在非节段性白癜风（NSV）中。在这项研究中，我们确定了转化生长因子β受体II（TGFBR2）基因是否有助于韩国人群中NSV的易感性。从415例对照和233例病例中采集了血液样本。我们在TGFBR2基因中选择了三个单核苷酸多态性（SNPs）。使用直接测序确定SNP的基因型。白癜风患者和对照组之间的所有SNP均显着不同（rs2005061，共显性，显性，隐性，P <0.05; rs3773645，共显性，显性，隐性，P <0.05; rs3773649，共显性，隐性， P <0.05）。此外，连锁不平衡（LD）单元的单体型1（CG）和单体型2（GA）也与NSV风险相关。本研究提示TGFBR2可能与NSV有关。

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