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首页> 外文期刊>International journal of immunogenetics >Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.
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Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

机译：IL10，IL19和IL20基因多态性与慢性乙型肝炎感染结局的评估。

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摘要

Hepatitis B virus (HBV) infection remains a serious global health problem despite the availability of a highly effective vaccine. Approximately 5% of HBV-infected adults develop chronic hepatitis B, which may result in liver cirrhosis or hepatocellular carcinoma. Variants of interleukin-10 (IL10) have been previously associated with chronic hepatitis B infection and progression to hepatocellular carcinoma. Single nucleotide polymorphisms (SNP; n = 42) from the IL10, IL19 and IL20 gene regions were examined for an association with HBV infection outcome, either chronic or recovered, in a nested case-control study of African Americans and European Americans. Among African Americans, three nominally statistically significant SNP associations in IL10, two in IL20, and one haplotype association were observed with different HBV infection outcomes (P = 0.005-0.04). A SNP (rs1518108) in IL20 deviated significantly from Hardy-Weinberg equilibrium in African Americans, with a large excess of heterozygotes in chronic HBV-infected cases (P = 0.0006), which suggests a strong genetic effect. Among European Americans, a nominally statistically significant SNP association in IL20 and an IL20 haplotype were associated with HBV recovery (P = 0.01-0.04). These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis.
机译：尽管可获得高效疫苗，但乙肝病毒（HBV）感染仍然是严重的全球健康问题。约有5％的HBV感染成人会发展为慢性乙型肝炎，这可能会导致肝硬化或肝细胞癌。先前已将白介素10（IL10）的变体与慢性乙型肝炎感染和发展为肝细胞癌有关。在一项针对非洲裔美国人和欧美人的嵌套病例对照研究中，检查了来自IL10，IL19和IL20基因区域的单核苷酸多态性（SNP; n = 42）与慢​​性或恢复性HBV感染结果的相关性。在非裔美国人中，观察到IL10中三个名义上具有统计学意义的SNP关联，IL20中两个，一个单体型关联具有不同的HBV感染结局（P = 0.005-0.04）。 IL20中的SNP（rs1518108）与非裔美国人的Hardy-Weinberg平衡显着不同，在慢性HBV感染病例中，杂合子大量过量（P = 0.0006），这表明其具有强大的遗传效应。在欧洲裔美国人中，IL20和IL20单倍型的名义上统计学上显着的SNP关联与HBV恢复相关（P = 0.01-0.04）。这些结果表明，IL10和IL20基因变异会影响HBV感染结果，并鼓励对这些细胞因子在HBV发病机理中的进一步研究。

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