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首页> 外文期刊>International journal of immunogenetics >HLA-A, B, Cw, DRB1, DQB1 and DPB1 alleles and haplotypes in the genetically homogenous Irish population.
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HLA-A, B, Cw, DRB1, DQB1 and DPB1 alleles and haplotypes in the genetically homogenous Irish population.

机译：遗传上同质的爱尔兰人口中的HLA-A，B，Cw，DRB1，DQB1和DPB1等位基因和单倍型。

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摘要

The frequencies of human leucocyte antigen (HLA) class I and II alleles and haplotypes of 250 Irish unrelated bone marrow donors were determined by high resolution polymerase chain reaction (PCR), using a combination of reverse line blot hybridization and PCR with sequence-specific primers. Phylogenetic analyses indicate that this Irish population is closely related to British, North-western European, American and Australian Caucasian populations. These observations are consistent with recognized historical, geographical, cultural, ethnic and linguistic relationships between these populations and suggest that Irish haematopoietic stem cell transplant recipients have a greater likelihood of finding a phenotypically matched donor within registries based on these populations. HLA-A, B, Cw, DRB1, DQB1 and DPB1 analysis confirms that this young homogenous population is characterized by features of a North-western European anthropological type with limited influence of additional ethnic haplotypes.
机译：通过高分辨率聚合酶链反应（PCR），结合反向线印迹杂交和PCR以及序列特异性引物，确定了250个爱尔兰无关骨髓供体的人类白细胞抗原（HLA）I和II类等位基因频率和单倍型。系统发育分析表明，该爱尔兰人口与英国，西北欧洲，美国和澳大利亚的白种人人口密切相关。这些观察结果与这些人群之间公认的历史，地理，文化，种族和语言关系是一致的，并且表明爱尔兰造血干细胞移植受者更有可能在基于这些人群的注册表中找到表型匹配的供体。 HLA-A，B，Cw，DRB1，DQB1和DPB1分析证实，这一年轻的同质人口的特征是西北北欧人类学类型的特征，而其他种族单倍型的影响有限。

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