首页> 外文期刊>International journal of immunopharmacology >Inhibitory effect of ginsenoside on the mediator release in the guinea pig lung mast cells activated by specific antigen-antibody reactions.
【24h】

Inhibitory effect of ginsenoside on the mediator release in the guinea pig lung mast cells activated by specific antigen-antibody reactions.

机译:人参皂甙对豚鼠肺肥大细胞中由特异性抗原抗体反应激活的介质释放的抑制作用。

获取原文
获取原文并翻译 | 示例
           

摘要

We reported that some components of ginsenosides decreased mediator release which was evoked by the activation of mast cells caused by specific antigen-antibody reactions. This study aimed to assess the effects of ginsenoside, Rb1, which belongs to the protopanaxadiol, on the mechanism of mediator release during mast cell activation. Pretreatment of Rb1 (100 microg) significantly decreased histamine and leukotriene in a dose-dependent manner during mast cell activation. The PLD activity during mast cell activation decreased in the pretreatment of Rb1 (300 microg). The amount of DAG produced by PLC activity decreased because of Rb1 pretreatment. The amount of mass DAG decreased due to Rb1 pretreatment during mast cell activation. Rb1 (300 microg) pretreatment strongly inhibited the incorporation of the [3H]methyl moiety into phospholipids. The data suggest that Rb1, purified from Korean Red Ginseng Radix, inhibits an increase of DAG production during mast cell activation caused by antigen-antibody reactions, which is mediated via phosphatidylcholine-PLD and phosphatidylinositol-PLC systems. This is then followed by the inhibition of histamine releases. Furthermore, Rb1 reduces the phosphatidylcholine production by inhibiting the methyl-transferase I and II, and the reduction of phosphatidylcholine production inhibits leukotriene release.
机译:我们报道了人参皂甙的某些成分降低了介质释放,这是由特定抗原-抗体反应引起的肥大细胞活化引起的。这项研究旨在评估人参皂甙Rb1(属于原托那沙二醇)对肥大细胞活化过程中介质释放机制的影响。在肥大细胞激活过程中,Rb1(100微克)的预处理以剂量依赖的方式显着降低了组胺和白三烯。肥大细胞激活过程中的PLD活性在Rb1(300微克)的预处理中降低。由于Rb1预处理,PLC活动产生的DAG量减少。由于肥大细胞活化过程中的Rb1预处理,质量DAG的量减少了。 Rb1(300微克)预处理强烈抑制[3H]甲基部分掺入磷脂中。数据表明,从高丽人参提取物纯化的Rb1抑制了肥大细胞活化过程中由抗原抗体反应引起的DAG产生的增加,抗原抗体反应是通过磷脂酰胆碱-PLD和磷脂酰肌醇-PLC系统介导的。然后抑制组胺释放。此外,Rb1通过抑制甲基转移酶I和II减少了磷脂酰胆碱的产生,而减少磷脂酰胆碱的产生则抑制了白三烯的释放。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号