...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of immunogenetics >CCR2 allele polymorphisms in 15 Chinese ethnic populations.
【24h】

CCR2 allele polymorphisms in 15 Chinese ethnic populations.

机译：CCR2等位基因多态性在中国15个民族中的分布。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chemokine receptor-2 (CCR2) is a co-receptor for the entry of human immunodeficiency virus-1 (HIV-1) into the target cells. A mutation in CCR2 (CCR2-64I) exhibited a protective effect to delay the progression of acquired immunodeficiency syndrome (AIDS). To study the mutant frequency and polymorphism of CCR2 in Chinese populations, 1082 individuals from 15 Chinese populations distributing widely from north to south were collected. The genotypes of CCR2-64I were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with the digestion of restriction endonuclease FokI. Of the 1082 individuals, 352 (32.53%) were carriers of CCR2-64I allele, 257 of whom (23.75%) were heterozygotes (CCR2-64V/I), whereas 95 (8.78%) were homozygotes (CCR2-64V/V). The frequency of the CCR2-64I allele in those tested individuals was 20.66%. This prevalence of CCR2-64I was higher than what was known for American and European populations. Moreover, the frequencies of CCR2-64I were generally higher in northern China than they were in southern China, and the frequencies had significant variance in 15 populations of China (chi2 = 27.135, P = 0.018).
机译：趋化因子受体2（CCR2）是人类免疫缺陷病毒1（HIV-1）进入靶细胞的共同受体。 CCR2突变（CCR2-64I）表现出保护作用，可延缓获得性免疫缺陷综合症（AIDS）的进展。为了研究CCR2在中国人群中的突变频率和多态性，收集了从15个中国人群中南北分布的1082个人。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和限制性内切核酸酶FokI的消化来确定CCR2-64I的基因型。在1082个个体中，有352个（32.53％）是CCR2-64I等位基因的携带者，其中257个（23.75％）是杂合子（CCR2-64V / I），而95个（8.78％）是纯合子（CCR2-64V / V） 。在那些测试的个体中，CCR2-64I等位基因的频率为20.66％。 CCR2-64I的患病率高于美国和欧洲人口。此外，CCR2-64I的频率在中国北方普遍高于中国南部，并且在中国15个人口中，这些频率具有显着差异（chi2 = 27.135，P = 0.018）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号