A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria.

Temple SE; Almeida CM; Cheong KY; Wunderink RG; Waterer GW

首页> 外文期刊>International journal of immunogenetics >A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria.

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A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria.

机译：淋巴毒素α基因中的双型与革兰氏阳性和革兰氏阴性细菌诱导的LTA mRNA的差异表达有关。

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We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.

机译：我们对淋巴毒素α（LTA）启动子进行了测序，并确定了与LTA252G> A和LTA723C> A紧密连接的LTA10G> A。来自LTA723AA：LTA252GG：LTA10AA个体的刺激细胞比LTA723CC：LTA252AA：LTA10GG和LTA723AA：LTA252AG：LTA10GA个体具有显着更高的LTA mRNA水平，这表明该双倍型可能包含功能性多态性，解释了观察到的与LTA252G> A的疾病关联。

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来源
《International journal of immunogenetics》 |2007年第3期|共4页
作者
Temple SE; Almeida CM; Cheong KY; Wunderink RG; Waterer GW;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
latent transition analysis; RNA; Messenger; Lymphotoxin; Bacterial; Genes; RNA; 信使; 淋巴毒素; 基因;

机译：latent transition analysis;RNA;Messenger;Lymphotoxin;Bacterial;Genes;RNA;信使;淋巴毒素;基因;

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1. A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria. [J] . Temple SE, Almeida CM, Cheong KY, International journal of immunogenetics . 2007,第3期

机译：淋巴毒素α基因中的双型与革兰氏阳性和革兰氏阴性细菌诱导的LTA mRNA的差异表达有关。
2. Polymorphisms in lymphotoxin alpha and CD14 genes influence TNFalpha production induced by Gram-positive and Gram-negative bacteria. [J] . Temple SE, Cheong KY, Almeida CM, Genes and immunity. . 2003,第4期

机译：淋巴毒素α和CD14基因的多态性影响革兰氏阳性和革兰氏阴性细菌诱导的TNFα产生。
3. IFN-alpha priming of human monocytes differentially regulates gram-positive and gram-negative bacteria-induced IL-10 release and selectively enhances IL-12p70, CD80, and MHC class I expression. [J] . Hermann P, Rubio M, Nakajima T, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第4期

机译：人单核细胞的IFN-α引发差异调节革兰氏阳性和革兰氏阴性细菌诱导的IL-10释放，并选择性增强IL-12p70，CD80和MHC I类表达。
4. Differential Gene Expression Using mRNA Isolated on Plastic Microfluidic Chips [C] . Arpita Bhattacharyya, Catherine M. Klapperich Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2009

机译：使用mRNA的差异基因表达在塑料微流体芯片上孤立
5. Iron uptake in Gram-negative and Gram-positive bacteria. [D] . Jin, Bo. 2006

机译：革兰氏阴性和革兰氏阳性细菌中的铁吸收。
6. Differential Tumor Necrosis Factor Alpha Expression and Release from Peritoneal Mouse Macrophages In Vitro in Response to Proliferating Gram-Positive versus Gram-Negative Bacteria [O] . Wei Cui, David C. Morrison, Richard Silverstein 2000

机译：差异性肿瘤坏死因子α表达和从腹膜小鼠巨噬细胞释放体外对增殖革兰氏阳性细菌与革兰氏阴性细菌的响应
7. Polymorphisms in lymphotoxin alpha and CD14 genes influence TNFα production induced by Gram-positive and Gram-negative bacteria [O] . S E L Temple, K Y Cheong, C M Almeida, 2003

机译：LymPhotoxinα和CD14基因中的多态性影响革兰氏阳性和革兰氏阴性细菌诱导的TNFα

A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria.

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