...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of immunogenetics >Variability in TRBV haplotype frequency and composition in Caucasian, African American, Western African and Chinese populations.
【24h】

Variability in TRBV haplotype frequency and composition in Caucasian, African American, Western African and Chinese populations.

机译：高加索人，非裔美国人，西非和中国人口中TRBV单倍型频率和组成的变异性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The polymorphic T-cell receptor Vbeta (TRBV) genes encode much of the variable region of the T-cell receptor beta chain. Analysis of allele frequencies of three closely linked polymorphic TRBV genes, TRBV7-3, TRBV9 and TRBV6-4, was undertaken in several populations. The frequencies of these alleles are not significantly different in populations of Caucasians, African Americans and Western Africans. However, Chinese population is extremely homogenous at all three loci. The current study identifies the existence of haplotypic relationships between alleles of these genes in the Caucasian population. The ORF allele TRBV7-3*A3 is found exclusively on chromosomes bearing TRBV9*A2 and TRBV6-4*A2 in this cohort. In contrast, TRBV7-3*A1 and the null allele TRBV7-3*A2 are associated only with TRBV9*A1 and TRBV6-4*A1. This pattern of linkage disequilibrium (LD) is altered in the African American and Western African populations. In these cohorts, there is a marked reduction in LD between alleles of TRBV7-3 and TRBV9. This study is consistent with previous population genetic studies wherein African-derived samples have a greater level of genetic diversity compared to Caucasians. These data also demonstrate that patterns of LD are not consistent across the entire TRBV locus.
机译：多态性T细胞受体Vbeta（TRBV）基因编码T细胞受体β链的许多可变区。在几个人群中分析了三个紧密连锁的多态TRBV基因TRBV7-3，TRBV9和TRBV6-4的等位基因频率。这些等位基因的频率在高加索人，非裔美国人和西非人人群中没有显着差异。但是，在这三个基因座上，中国人口极为同质。当前的研究确定了白种人中这些基因的等位基因之间存在单倍型关系。在该队列中，仅在带有TRBV9 * A2和TRBV6-4 * A2的染色体上发现ORF等位基因TRBV7-3 * A3。相反，TRBV7-3 * A1和无效等位基因TRBV7-3 * A2仅与TRBV9 * A1和TRBV6-4 * A1相关。在非裔美国人和西非人口中，这种连锁不平衡的模式发生了变化。在这些队列中，TRBV7-3和TRBV9等位基因之间的LD显着降低。这项研究与以前的人口遗传研究一致，在非洲，与高加索人相比，非洲衍生的样本具有更高的遗传多样性。这些数据还表明，LD的模式在整个TRBV基因座上不一致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号