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首页> 外文期刊>International journal of immunogenetics >Association of interleukin-16 polymorphisms with disease progression and susceptibility in endometriosis
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Association of interleukin-16 polymorphisms with disease progression and susceptibility in endometriosis

机译：白细胞介素16多态性与子宫内膜异位症疾病进展和易感性的关系

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Interleukin-16 (IL-16) is a multifunctional pro-inflammatory cytokine that was previously found in association with complex disorders, and it is now cleared that this cytokine plays a critical role in regulation of cellular functions such as homoeostasis. Due to the complexity of endometriosis and its resemblance to cancer, we designed present case-control study to determine the effects of genetic polymorphisms of the human IL-16 gene on Iranian women's susceptibility to endometriosis. A total of 126 patients with endometriosis (stages I-IV) and 144 healthy women as control group were recruited to the study. We genotyped four single nucleotide polymorphisms of IL-16 gene (rs11556218 T>G, rs4778889 T>C, rs4072111 C>T and rs1131445 C>T). Genotyping was performed using PCR and restriction fragment length polymorphism. Our results showed that genotype distribution in two exonic polymorphisms including rs11556218 and rs4072111 was significantly different between Endometriosis patients and healthy individuals (P<0.05). We have also found an association between rs4072111 and rs1131445 with progression to the severe stages (III-IV) of endometriosis (P<0.05). Finally, we may conclude that IL-16 gene polymorphisms are highly associated with increased risk of endometriosis and could be considered as a susceptibility factor for endometriosis.
机译：白细胞介素16（IL-16）是一种多功能的促炎性细胞因子，以前与复杂的疾病有关，现在已经清楚，这种细胞因子在调节细胞功能（如止血）中起关键作用。由于子宫内膜异位症的复杂性及其与癌症的相似性，我们设计了本病例对照研究来确定人IL-16基因的遗传多态性对伊朗女性子宫内膜异位症易感性的影响。总共招募了126名子宫内膜异位患者（I-IV期）和144名健康女性作为对照组。我们对IL-16基因的四个单核苷酸多态性进行了基因分型（rs11556218 T> G，rs4778889 T> C，rs4072111 C> T和rs1131445 C> T）。使用PCR和限制性片段长度多态性进行基因分型。我们的结果表明，子宫内膜异位症患者与健康个体的两个外显子多态性（包括rs11556218和rs4072111）的基因型分布存在显着差异（P <0.05）。我们还发现rs4072111和rs1131445与子宫内膜异位症的严重阶段（III-IV）进展相关（P <0.05）。最后，我们可以得出结论，IL-16基因多态性与子宫内膜异位症的风险增加高度相关，可以被认为是子宫内膜异位症的易感因素。

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