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首页> 外文期刊>International journal of immunogenetics >Association of TIM-1 5383-5397ins/del and TIM-3-1541C > T polymorphisms with multiple sclerosis in Isfahan population
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Association of TIM-1 5383-5397ins/del and TIM-3-1541C > T polymorphisms with multiple sclerosis in Isfahan population

机译：伊斯法罕人群中TIM-1 5383-5397ins / del和TIM-3-1541C> T多态性与多发性硬化的关系

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摘要

Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in autoimmune diseases. In this study, for the first time, the association of TIM-1 5383-5397ins/del and TIM-3 -1541C>T polymorphisms with MS in an Iranian population was considered. The results of our study showed that there is no significant association between TIM-1 5383-5397ins/del and MS (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS (P = 0.009, OR = 4.08).
机译：多发性硬化症（MS）是中枢神经系统的一种器官特异性自身免疫性疾病，全世界约有250万人受其影响。据报道，在自身免疫性疾病中，两种新发现的免疫调节分子TIM-1和TIM-3可能参与其中。在本研究中，首次考虑了伊朗人群中TIM-1 5383-5397ins / del和TIM-3 -1541C> T多态性与MS的关联。我们的研究结果表明，TIM-1 5383-5397ins / del与MS之间无显着关联（P = 0.38）;然而，患者组的CT基因型TIM-3 -1541C> T的频率明显高于对照组，并且CT基因型与MS之间存在显着相关性（P = 0.009，OR = 4.08）。

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