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首页> 外文期刊>International journal of immunogenetics >Susceptible and protective associations of HLA DRB1*/DQB1*alleles and haplotypes with ischaemic stroke
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Susceptible and protective associations of HLA DRB1*/DQB1*alleles and haplotypes with ischaemic stroke

机译：HLA DRB1 * / DQB1 *等位基因和单倍型与缺血性卒中的易感性和保护性关联

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摘要

Stroke has emerged as the second commonest cause of mortality worldwide and is a major public health problem. For the first time, we present here the association of human leucocyte antigen (HLA)-DRB1*/DQB1* alleles and haplotypes with ischaemic stroke in South Indian patients. Ischaemic stroke (IS) cases and controls were genotyped for HLA-DRB1*/DQB1* alleles by polymerase chain reaction sequence-specific primers (PCR-SSP) method. The frequencies of HLA class II alleles such as DRB1*04, DRB1*07, DRB1*11, DRB1*12, DRB1*13, DQB1*02 and DQB1*07 were high in IS patients than in the age-and gender-matched controls, suggesting that the individuals with these alleles are susceptible to ischaemic stroke in South India. The frequencies of alleles such as DRB1*03, DRB1*10, DRB1*14, DQB1*04 and DQB1*05 were less in IS cases than in the controls, suggesting a protective association. Haplotypes DRB1*04-DQB1*0301, DRB1*07-DQB1*02, DRB1*07-DQB1*0301, DRB1*11-DQB1*0301 and DRB1*13-DQB1*06 were found to be high in IS patients conferring susceptibility. The frequency of haplotype DRB1*10-DQB1*05 was high in controls conferring protection. IS-LVD and gender-stratified analysis too confirmed these susceptible and protective associations. Thus, HLA-DRB1*/DQB1* alleles and haplotypes strongly predispose South Indian population to ischaemic stroke. Further studies in different populations with large sample size or the meta-analysis are needed to explain the exact mechanism of associations of HLA gene(s) with IS.
机译：中风已成为全球第二大死亡原因，并且是主要的公共卫生问题。我们首次在这里介绍南印度患者中人类白细胞抗原（HLA）-DRB1 * / DQB1 *等位基因和单倍型与缺血性卒中的关系。通过聚合酶链反应序列特异性引物（PCR-SSP）方法对HLA-DRB1 * / DQB1 *等位基因对缺血性中风（IS）病例和对照进行基因分型。 IS患者的HLA II类等位基因频率如DRB1 * 04，DRB1 * 07，DRB1 * 11，DRB1 * 12，DRB1 * 13，DQB1 * 02和DQB1 * 07高于年龄和性别匹配的患者对照，表明这些等位基因的个体在南印度易患缺血性中风。在IS病例中，等位基因如DRB1 * 03，DRB1 * 10，DRB1 * 14，DQB1 * 04和DQB1 * 05的频率低于对照组，表明存在保护性关联。在易感性IS患者中发现单倍型DRB1 * 04-DQB1 * 0301，DRB1 * 07-DQB1 * 02，DRB1 * 07-DQB1 * 0301，DRB1 * 11-DQB1 * 0301和DRB1 * 13-DQB1 * 06高。在提供保护的对照中，单倍型DRB1 * 10-DQB1 * 05的频率较高。 IS-LVD和按性别分层的分析也证实了这些易感性和保护性关联。因此，HLA-DRB1 * / DQB1 *等位基因和单倍型强烈使南印度人易患缺血性中风。需要在大样本量的不同人群中进行进一步研究或进行荟萃分析，以解释HLA基因与IS关联的确切机制。

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