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首页> 外文期刊>International journal of medical microbiology: IJMM >Identification of new endemic tick-borne encephalitis foci in Poland - a pilot seroprevalence study in selected regions
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Identification of new endemic tick-borne encephalitis foci in Poland - a pilot seroprevalence study in selected regions

机译：在波兰鉴定新的地方性tick传播脑炎疫源地-在部分地区进行的血清流行性试验研究

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In Poland. large-scale serologic surveys carried out in 1965-1972 revealed regions of Poland with particularly high prevalences of antibodies against tick-borne encephalitis virus (TBEV). The information provided by the routine surveillance of communicable diseases during 1970-2005 indicated, however, that the geographic distribution of the disease is limited to a few eastern and south-western regions of Poland (defined as endemic for the purpose of this study). In the present serologic survey, 1498 human serum samples collected in 1996-2005 were randomly selected from a serum bank, and 358 goat serum samples were collected from milk-producing farms in selected areas of Poland 2002-2006. Thirty-nine human samples were positive for anti-TBEV antibodies, with an overall seroprevalence of 2.6%. Seroprevalence in endemic provinces ranged from 0.8% to 4.3%, and seroprevalence in non-endemic provinces ranged from 1.9% to 4.3%. In endemic, compared to the non-endemic provinces, the highest seroprevalence was found in the age group > 60 years (7% vs. 1%) and in inhabitants of villages (3.9% vs. 1.8%). In non-endemic, compared to endemic provinces. the highest seroprevalence was detected in the age groups 30-39 years (5% vs. 2%) and 40-49 (4% vs. 0%), and in inhabitants of large towns inhabited by > 100,000 people (4.1 % vs. 2.5%). Out of 358 goat samples, 17 (4.7%) were positive for anti-TBEV antibodies. Seroprevalence in goats reached 14/151 (9.3%) in endemic, and 3/207 (1.4%) in non-endemic provinces. The present study indicates the possible existence of endemic foci in north-western provinces of Poland, in which barely any cases were reported during 1970-2005. The socio-demographic profile of seropositive subjects in non-endemic regions suggests that they might have been exposed to TBEV during travels to known endemic regions. This would mean, however, that they were missed by the surveillance system. A thorough review of diagnostic protocols in non-endemic regions and work towards an improvement of the TBE surveillance sensitivity is necessary. (c) 2008 Elsevier GmbH. All rights reserved.
机译：在波兰。 1965年至1972年进行的大规模血清学调查显示，波兰的tick传播性脑炎病毒（TBEV）抗体感染率特别高。但是，1970年至2005年例行的传染病常规监测所提供的信息表明，该疾病的地理分布仅限于波兰的东部和西南部地区（在本研究中定义为地方性）。在本次血清学调查中，从血清库中随机抽取了1996-2005年收集的1498份人血清样本，并从2002-2006年波兰部分地区的产奶场中收集了358份山羊血清样本。 39个人类样品的抗TBEV抗体呈阳性，总血清阳性率为2.6％。地方病省的血清流行率在0.8％至4.3％之间，非地方病省的血清流行率在1.9％至4.3％之间。与非地方病省相比，地方病的血清流行率最高的是> 60岁的年龄组（7％对1％）和乡村居民（3.9％对1.8％）。在非地方病省相比。在30-39岁年龄段（5％vs. 2％）和40-49岁年龄段（4％vs. 0％）中以及在100,000人以上的大城镇居民中发现最高的血清阳性率（4.1％vs. 2.5％）。在358个山羊样品中，有17个（4.7％）的抗TBEV抗体呈阳性。在地方病中，山羊的血清阳性率达到14/151（9.3％），在非地方病省达到3/207（1.4％）。本研究表明波兰西北省可能存在地方性病灶，在1970-2005年间几乎没有报告病例。在非流行地区，血清阳性患者的社会人口统计学资料表明，他们在前往已知的流行地区旅行时可能曾接触过TBEV。但是，这意味着监视系统会错过它们。有必要对非流行地区的诊断方案进行彻底审查，并努力提高TBE监测的敏感性。 （c）2008 Elsevier GmbH。版权所有。

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