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首页> 外文期刊>International journal of medical microbiology: IJMM >Pseudonzonas aeruginosa and Burkholderia cepacia in cystic fibrosis: genome evolution, interactions and adaptation
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Pseudonzonas aeruginosa and Burkholderia cepacia in cystic fibrosis: genome evolution, interactions and adaptation

机译：铜绿假单胞菌和洋葱伯克霍尔德氏菌在囊性纤维化中的作用：基因组进化，相互作用和适应

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摘要

The Gram-negative bacteria Pseudomonas aeruginosa and Burkholderia cepacia are opportunistic human pathogens that are responsible for severe nosocomial infections in immunocompromised patients and are the major pathogens in cystic fibrosis (CF). The two bacteria not only inhabit the same environmental niches but can also form mixed biofilms in the lungs of CF patients. Hence, it appears very likely that the two organisms are capable of interacting with each other. Work of the past few years has shown that both bacteria utilize quorum-sensing systems, which rely on N-acylhomoserine lactone signal molecules, to control the expression of virulence factors and biofilm development. Most importantly, evidence has been presented that these signal molecules also serve as a universal language for communication between the two organisms. Moreover, analyses of the diversity in P. aeruginosa revealed the presence of genome islands that contain genes that are highly homologous to genes identified in strains of Burkholderia sp. This finding suggests that there is a frequent exchange of genetic material between the two organisms. (C) 2004 Elsevier GmbH. All rights reserved.
机译：革兰氏阴性细菌铜绿假单胞菌和洋葱伯克霍尔德菌是机会性人类病原体，是免疫受损患者严重医院感染的原因，并且是囊性纤维化（CF）的主要病原体。这两种细菌不仅居住在相同的环境环境中，而且还可以在CF患者的肺部形成混合的生物膜。因此，这两种生物很可能能够相互作用。过去几年的工作表明，这两种细菌都利用群体感应系统，该系统依靠N-酰基高丝氨酸内酯信号分子来控制毒力因子的表达和生物膜的发育。最重要的是，已经有证据表明这些信号分子也可以作为两种生物之间交流的通用语言。此外，对铜绿假单胞菌多样性的分析表明存在基因组岛，其包含与伯克霍尔德菌属菌株中鉴定出的基因高度同源的基因。这一发现表明，两种生物之间遗传物质的交换频繁。 （C）2004 Elsevier GmbH。版权所有。

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