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首页> 外文期刊>International journal of medical microbiology: IJMM >CpG-DNA as immune response modifier
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CpG-DNA as immune response modifier

机译：CpG-DNA作为免疫应答调节剂

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Toll-like receptors (TLRs) have been recognized to play a fundamental role in the recognition of microbial pathogens and the activation of innate immunity. However, it has also turned out that triggering of TLRs with purified compounds or synthetic ligands represents a powerful means to modulate innate as well as adaptive immune responses. Among the substances currently under investigation as immune response modifiers CpG-DNA has gained particular interest. One reason for this is the feasibility to easily synthesize and modify immunostimulatory CpG-containing oligodeoxynucleotides (CpG-ODNs). This review deals with the structural needs of CpG-ODNs. CpG-ODNs are discussed as being composed of distinct building blocks (e.g. sequence strings, backbone modifications) giving rise to a concept of structural modules within CpG-ODNs. (C) 2004 Elsevier GmbH. All rights reserved.
机译：已经认识到Toll样受体（TLR）在识别微生物病原体和激活先天免疫中起基本作用。然而，还发现，用纯化的化合物或合成配体触发TLR代表了一种调节先天性和适应性免疫反应的有力手段。在目前正在研究的作为免疫应答调节剂的物质中，CpG-DNA引起了特别的兴趣。其原因之一是容易合成和修饰含有免疫刺激性的含CpG的寡脱氧核苷酸（CpG-ODN）的可行性。该审查涉及CpG-ODN的结构需求。讨论了CpG-ODN由不同的构件（例如序列字符串，骨架修饰）组成，从而引起了CpG-ODN内结构模块的概念。 （C）2004 Elsevier GmbH。版权所有。

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