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Study of chitosan coatings on nanoparticles for biomedical applications

机译：用于生物医学应用的纳米颗粒上的壳聚糖涂层的研究

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摘要

Of late, much work and interest had been generated in the fields involving nanoparticles. Due to their nanometer scale, these particles have been proven to be promising in diverse applications such as electronics and medicine, amongst others. In addition, an emerging and attractive use of nanoparticles as biother apeutic delivery agents within the body was introduced. However, in order to use these nanoparticles in any biomedical application, they must be rendered biocompatible. In this paper, we attempt to coat chitosan, a naturally-occurring polymer which is biocompatible, biodegradable and nontoxic, onto the surfaces of nanoparticles. 5 nm gold (Au) nanoparticles were chosen for our study as they are commercially available. The presence of a chitosan shell not only renders these nanoparticles biocompatible, the amino and hydroxyl groups of chitosan also allow the immobilization of many biother-apeutic agents. The relationship between the concentration of the chitosan used in the coating process and the thickness of the chitosan shell formed is investigated. It is hoped that the results of this study can also be applied to other nanoparticles, in addition to Au, that are intended to be used in bioapplications.
机译：最近，在涉及纳米颗粒的领域中已经产生了很多工作和兴趣。由于其纳米级，这些颗粒已被证明在电子和医学等各种应用中很有前途。另外，引入了纳米颗粒作为生物体内载脂蛋白递送剂在体内的新兴和有吸引力的用途。然而，为了在任何生物医学应用中使用这些纳米颗粒，必须使其具有生物相容性。在本文中，我们尝试将壳聚糖（一种生物相容，可生物降解且无毒的天然存在的聚合物）包被在纳米粒子表面上。我们选择了5 nm金（Au）纳米颗粒作为研究对象，因为它们是可商购的。壳聚糖壳的存在不仅使这些纳米颗粒具有生物相容性，壳聚糖的氨基和羟基还可以固定许多生物治疗剂。研究了涂布过程中所用壳聚糖的浓度与所形成的壳聚糖壳的厚度之间的关系。希望这项研究的结果也可以应用于打算用于生物应用的除Au以外的其他纳米颗粒。

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