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首页> 外文期刊>International journal of molecular medicine >Electroacupuncture at the Quchi and Zusanli acupoints exerts neuroprotective role in cerebral ischemia-reperfusion injured rats via activation of the PI3K/Akt pathway
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Electroacupuncture at the Quchi and Zusanli acupoints exerts neuroprotective role in cerebral ischemia-reperfusion injured rats via activation of the PI3K/Akt pathway

机译：电针曲池穴和祖三里穴通过激活PI3K / Akt通路在脑缺血再灌注损伤大鼠中发挥神经保护作用

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摘要

The PI3K/Akt pathway, a critical mediator of cell survival, is suppressed in cerebral ischemia/reperfusion (I/R) injury; therefore, it is a major focus in treatment of ischemic stroke. Acupuncture has long been used in China to clinically treat stroke. However, the precise mechanism of its neuroprotective activities remains largely unknown. Using a focal cerebral I/R injured rat model, in the present study we evaluated the in vivo therapeutic efficacy of electroacupuncture and investigated the underlying molecular mechanisms. We found that electroacupuncture at Quchi (LI11) and Zusanli (ST36) acupoints on the contralateral paralyzed limb significantly improved neurological deficits and cerebral infarction. In addition, electroacupuncture profoundly activated PI3K/Akt signaling in ischemic cerebral tissues. Consequently, the upregulatory effect of electroacupuncture on PI3K/Akt activation resulted in the inhibition of cerebral cell apoptosis. Moreover, electroacupuncture increased the serum secretion levels of the PI3K activators BDNF and GDNF, as well as upregulated the anti-apoptotic Bcl-2/Bax ratio in ischemic cerebrum. Our data suggest that electroacupuncture at Quchi and Zusanli acupoints exerts neuroprotective function in ischemic stroke via activation of the PI3K/Akt pathway.
机译：PI3K / Akt途径是细胞存活的关键介质，在脑缺血/再灌注（I / R）损伤中受到抑制;因此，它是缺血性中风的主要治疗重点。针灸在中国长期以来一直用于临床治疗中风。但是，其神经保护活性的确切机制仍是未知之数。使用局灶性脑I / R损伤大鼠模型，在本研究中，我们评估了电针的体内治疗功效并研究了潜在的分子机制。我们发现对侧瘫痪肢体的曲奇（LI11）和祖三里（ST36）穴位的电针可显着改善神经功能缺损和脑梗塞。此外，电针深刻激活了缺血性脑组织中的PI3K / Akt信号传导。因此，电针对PI3K / Akt激活的上调作用导致脑细胞凋亡的抑制。此外，电针提高了PI3K激活剂BDNF和GDNF的血清分泌水平，并上调了缺血性大脑中抗凋亡Bcl-2 / Bax的比例。我们的数据表明，曲奇穴位和祖三里穴位的电针通过激活PI3K / Akt途径在缺血性中风中发挥神经保护功能。

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