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首页> 外文期刊>International journal of PIXE >Application of micro beam PIXE in biomedical implant research
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Application of micro beam PIXE in biomedical implant research

机译：微束PIXE在生物医学植入物研究中的应用

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摘要

The material composition and surface structure of dental and orthopaedic implants influence the integration in bone, and, at the same time, the release of the constituent elements of the implants into the surrounding tissues. Titanium, titanium alloys (Ti-6A1-4V) and other materials which are considered to be biocompatible materials, release metal ions into the surrounding tissues. This may affect the appropriate biological response of the tissues to the implanted materials. The toxicity of some of the constituent elements of these implants, e.g. vanadium, is a matter of serious concern. In this paper, the experimental data on application of PIXE to biomedical-implant research are presented. Two groups of samples were prepared for PIXE analysis. The first group consisted of the specimens that were retrieved from the tissues around implants in 28 rats. The second group consisted of specimens that were sliced and polished to a thickness of a few 10 /an, while keeping the interface between the implant, cortical bone, bone marrow, and soft tissues intact. The implants of the second group, 10 specimens with between 6 and 20 measurement points on each specimen, were used for specifically obtaining the distribution of the released elements with reference to the implant tissue interface, using ion micro beam. The implantation time ranged from 12 weeks to 52 weeks.
机译：牙科和整形外科植入物的材料组成和表面结构会影响骨骼的整合，同时会影响植入物的组成元素向周围组织的释放。钛，钛合金（Ti-6A1-4V）和其他被认为是生物相容性材料的材料将金属离子释放到周围组织中。这可能会影响组织对植入材料的适当生物学反应。这些植入物的某些组成元素的毒性，例如钒，是一个值得严重关注的问题。本文介绍了将PIXE应用于生物医学植入物研究的实验数据。准备两组样品进行PIXE分析。第一组包括从28只大鼠的植入物周围组织中获取的标本。第二组由标本切成薄片并打磨至厚度为10 / an，同时保持植入物，皮质骨，骨髓和软组织之间的界面完好无损。第二组植入物是10个样本，每个样本的测量点在6至20个测量点之间，用于通过离子微束具体​​获取相对于植入物组织界面的释放元素的分布。植入时间为12周至52周。

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