Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption.

Varum FJ; Merchant HA; Basit AW

首页> 外文期刊>International Journal of Pharmaceutics >Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption.

【24h】

Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption.

机译：运动中的口服调释制剂：胃肠道转运与药物吸收之间的关系。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Oral modified-release dosage forms can be designed with the aim of achieving specific pharmacokinetic profiles, delivering to specific gut localities or reducing the number of drug administrations. Multiple-unit systems, such as pellets, beads or granules, often claim superiority to single-unit modified-release formulations in terms of predictability and reproducibility of behaviour in the gastrointestinal tract. This is an oversimplification and in this review we discuss the effect of the highly variable gastrointestinal transit on the bioperformance of multiple-unit dosage forms, relative to their single-unit counterparts. We examine the sometimes contradictory literature in this area and highlight specific case studies which demonstrate the effect of intestinal transit on dosage form performance and drug absorption.

机译：可以设计口服调释剂型，以达到特定的药代动力学特征，递送至特定的肠道部位或减少给药次数。就胃肠道中行为的可预测性和可再现性而言，多单元系统（例如药丸，珠子或颗粒）通常要求优于单单元调释制剂。这是一个过分的简化，在本综述中，我们将讨论高度可变的胃肠道转运对多单位剂型（相对于其单单位对应物）的生物性能的影响。我们研究了这一领域中有时相互矛盾的文献，并重点介绍了具体案例研究，这些研究证明了肠道运输对剂型性能和药物吸收的影响。

著录项

来源
《International Journal of Pharmaceutics》 |2010年第2期|共11页
作者
Varum FJ; Merchant HA; Basit AW;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption. [J] . Varum FJ, Merchant HA, Basit AW International Journal of Pharmaceutics . 2010,第1a2期

机译：运动中的口服调释制剂：胃肠道转运与药物吸收之间的关系。
2. Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption. [J] . Varum FJ, Merchant HA, Basit AW International Journal of Pharmaceutics . 2010,第1a2期

机译：口服改性释放制剂在运动中：胃肠道转换与药物吸收之间的关系。
3. Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption. [J] . Varum FJ, Merchant HA, Basit AW International Journal of Pharmaceutics . 2010,第1a2期

机译：口服改性释放制剂在运动中：胃肠道转换与药物吸收之间的关系。
4. Drug Properties and Formulation Design Considerations in Developing Oral Modified-Release Products [C] . Yihong Qiu CPA/AAPS/FIP Joint Symposium on Pharmaceutical Science . 2002

机译：开发口服修饰发布产品的药物特性和配方设计注意事项
5. 1. Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications. 2. Development of crushable enteric-coated formulations. 3. Development of leaky enteric-coated pellets formulations. [D] . Watanalumlerd, Prapoch. 2004

机译：1.胃肠道转运对肠溶微丸制剂中药物药代动力学的影响的药代动力学建模和模拟及其应用。 2.开发可压碎的肠溶衣制剂。 3.开发泄漏的肠溶丸剂。
6. Relationship between systemic drug absorption and gastrointestinal transit after the simultaneous oral administration of carbamazepine as a controlled-release system and as a suspension of 15N-labelled drug to healthy volunteers. [O] . I R Wilding, S S Davis, J G Hardy, 1991

机译：同时向健康志愿者口服卡马西平作为控释系统和15N标记药物的悬浮液后全身药物吸收与胃肠道转运之间的关系。
7. Relationship between systemic drug absorption and gastrointestinal transit after the simultaneous oral administration of carbamazepine as a controlled-release system and as a suspension of 15N-labelled drug to healthy volunteers. [O] . Wilding, I R, Davis, S S, Hardy, J G, 1991

机译：同时向健康志愿者口服卡马西平作为控释系统和15N标记药物的悬浮液后，全身药物吸收与胃肠道转运之间的关系。

Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption.

摘要

著录项

相似文献

相关主题

期刊订阅