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首页> 外文期刊>International Journal of Pharmaceutics >Holmium-lipiodol-alginate microspheres for fluoroscopy-guided embolotherapy and multimodality imaging
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Holmium-lipiodol-alginate microspheres for fluoroscopy-guided embolotherapy and multimodality imaging

机译：碘化碘化海藻酸钠微球用于荧光镜引导的栓塞治疗和多模态成像

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Embolotherapy is a minimally invasive transcatheter technique aiming at reduction or complete obstruction of the blood flow by infusion of micro-sized particles in order to induce tumor regression. A major drawback of the current commercially available and clinically used microspheres is that they cannot be detected in vivo with medical imaging techniques, impeding intra- and post-procedural feedback. It can be expected that real-time monitoring of microsphere infusion and post-procedural imaging will result in better predictability and higher efficacy of the treatment. In this study, a novel microsphere formulation has been developed that can be visualized with fluoroscopy, X-ray computed tomography (CT) and magnetic resonance imaging (MRI). The microspheres were prepared with the JetCutter technique and consist of alginate ( matrix-forming polymer), holmium (cross-linking and MRI contrast agent), lipiodol ( radiopaque contrast agent) and Pluronic F-68 ( surfactant). The mean size ( SEM) of the hydrated holmium- lipiodol- alginate microspheres ( Ho- lip- ams) was 570 12mmwith a holmium content of 0.38 0.01% ( w/ w). Stability studies showed that the microspheres remained intact during incubation for two weeks in fetal calf serum ( FCS) at 37 C. The inclusion of lipiodol in the microspheres rendered excellent visualization capabilities for fluoroscopy and CT, whereas the holmium ions, which keep the alginate network together, also allow MR imaging. In this study it was shown that single sphere detectionwas possible by fluoroscopy, CT and MRI. The Ho- lip- ams were visualized in realtime, during infusion in a porcine kidney using fluoroscopy, and post- procedural, the deposition of the microspheres was examined with fluoroscopy, ( cone beam rotational) CT and MRI. The different imaging modalities showed similar deposition patterns of the microspheres within the organ. The combination of intra- procedural visualization, multimodality imaging for patient follow- up and the possibility of quantification offers a new and promising method for more safe, efficient and successful embolization treatment. a 2014 Elsevier B. V. All rights reserved.
机译：栓塞疗法是一种微创的经导管技术，旨在通过输注微小颗粒来减少或完全阻塞血流，从而诱导肿瘤消退。当前可商购的和临床上使用的微球的主要缺点是无法通过医学成像技术在体内检测到它们，从而阻碍了过程内和过程后的反馈。可以预料，对微球输注和过程后成像的实时监控将带来更好的可预测性和更高的治疗效果。在这项研究中，开发了一种新型的微球配方，可以通过荧光检查，X射线计算机断层扫描（CT）和磁共振成像（MRI）进行可视化。微球是用JetCutter技术制备的，由藻酸盐（形成基质的聚合物），（交联和MRI造影剂），碘油（不透射线的造影剂）和Pluronic F-68（表面活性剂）组成。水合-碘碘藻酸盐微球（Ho-lipams）的平均尺寸（SEM）为570 12mm，含量为0.38 0.01％（w / w）。稳定性研究表明，在37°C的胎牛血清（FCS）中温育两周后，微球保持完整。微球中包含的碘油使荧光镜和CT具有出色的可视化能力，而保留藻酸盐网络的离子则表现出出色的可视化能力。一起，还可以进行MR成像。在这项研究中表明，通过荧光检查，CT和MRI可以检测单个球体。使用荧光检查法在猪肾脏输注过程中实时可视化霍利普斯犬，手术后通过荧光检查，（锥形束旋转）CT和MRI检查微球的沉积情况。不同的成像方式显示了器官内微球的相似沉积模式。程序内可视化，用于患者随访的多模态成像以及量化可能性的结合，为更安全，有效和成功的栓塞治疗提供了一种新的有希望的方法。 a 2014 Elsevier B. V.保留所有权利。

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