Transport characteristics of ginkgolide B by Caco-2 cells and examination of ginkgolide B oral absorption potential using rat in situ intestinal loop method.

Lv H; Wang G; Wu X; Xie L; Huang C; Li H; Liang Y; Hao H; Sun J

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Transport characteristics of ginkgolide B by Caco-2 cells and examination of ginkgolide B oral absorption potential using rat in situ intestinal loop method.

机译：银杏内酯B通过Caco-2细胞的转运特性和使用大鼠原位肠loop法检查银杏内酯B的口服吸收潜能。

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The intestinal absorptive characteristics of ginkgolide B were investigated. The Caco-2 cells and the in situ closed loop were used as models of the intestinal mucosa to assess transepithelial transport of ginkgolide B. The determination of ginkgolide B was performed by HPLC-MS. In the Caco-2 cells, the absorptive transepithelial transport of ginkgolide B was pH dependent and the transport was enhanced at weakly acidic pH on the apical side. No concentration dependence and saturation were observed for the absorptive transport of ginkgolide B at concentrations up to 50muM. In the in situ closed loop, the absorption of ginkgolide B was intestinal segment-selective. The results indicate that the intestinal absorption of ginkgolide B in the upper intestine was significantly higher than that in the lower intestine.

机译：研究了银杏内酯B的肠道吸收特性。使用Caco-2细胞和原位闭环作为肠粘膜模型来评估银杏内酯B的上皮运输。通过HPLC-MS进行银杏内酯B的测定。在Caco-2细胞中，银杏内酯B的吸收性上皮转运取决于pH值，并且在弱酸性pH值下，顶侧的转运增强。在高达50μM的浓度下，银杏内酯B的吸收转运没有观察到浓度依赖性和饱和度。在原位闭环中，银杏内酯B的吸收是肠段选择性的。结果表明，银杏内酯B在小肠中的肠道吸收明显高于下小肠。

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来源
《International Journal of Pharmaceutics》 |2008年第2期|共5页
作者
Lv H; Wang G; Wu X; Xie L; Huang C; Li H; Liang Y; Hao H; Sun J;
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正文语种 eng
中图分类药学;
关键词
ginkgolide B; absorption characteristics; Oral; Patient Transport; Intestines; 肠;

机译：银杏内酯B;吸收特性;口服;患者转运;肠;肠;

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3. Transport characteristics of ginkgolide B by Caco-2 cells and examination of ginkgolide B oral absorption potential using rat in situ intestinal loop method. [J] . Lv H, Wang G, Wu X, International Journal of Pharmaceutics . 2008,第1a2期

机译：银杏内酯B通过Caco-2细胞的转运特性和使用大鼠原位肠loop法检查银杏内酯B的口服吸收潜能。
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8. Correction: Zhao J. et al. Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs. Molecules 2015 20 20031–20041 [O] . Jie Zhao, Ting Geng, Qi Wang, 2016

机译：更正：ZhaoJ.等。在Beagle犬中口服三种不同的银杏内酯B制剂后银杏内酯B的药代动力学。分子20152020031–20041
9. Correction: Zhao, J., et al. Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs. Molecules 2015, 20, 20031–20041 [O] . Jie Zhao, Ting Geng, Qi Wang, 2016

机译：更正：赵，J.，等。三种不同银杏内酯B制剂口服Beagle犬后银杏内酯B的药代动力学。分子2015,20,201001-20041

Transport characteristics of ginkgolide B by Caco-2 cells and examination of ginkgolide B oral absorption potential using rat in situ intestinal loop method.

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