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首页> 外文期刊>International Journal of Pharmaceutics >Emitted dose estimates from Seretide Diskus and Symbicort Turbuhaler following inhalation by severe asthmatics.
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Emitted dose estimates from Seretide Diskus and Symbicort Turbuhaler following inhalation by severe asthmatics.

机译：严重哮喘患者吸入后，来自Seretide Diskus和Symbicort Turbuhaler的剂量估计值。

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摘要

The dose emitted from dry powder inhalers may be inhalation flow-dependent. Using an ex vivo method, the Electronic Lung, we have measured the aerodynamic characteristics of the emitted dose for both active constituents from Seretide Diskus (salmeterol xinafoate 50 mcg; fluticasone propionate 500 mcg) and Symbicort Turbuhaler (formoterol 6 mcg; budesonide 200 mcg). Electronic inhalation profiles were collected from 20 severe asthmatics (mean PEFR 53% predicted) when they inhaled using a placebo Seretide Diskus and a placebo Symbicort Turbuhaler. These were replayed in the Electronic Lung with the respective active inhaler in situ. Mean(S.D.) peak inhalation flow rates (PIFR) through the Diskus and Turbuhaler were 94.7(32.9) and 76.8(26.2) l min(-1), respectively. From the Electronic Lung the Diskus inhalation profiles provided a mean(S.D.) fine particle dose (FPD) for fluticasone propionate and salmeterol of 20.4(4.8) and 18.4(4.4)% labelled dose. For Turbuhaler inhalation profiles the FPD was 23.1(12.9) and 20.7(11.1)% labelled dose for budesonide and formoterol, respectively. The linear (p < 0.001) relationships between FPD against PIFR for budesonide and formoterol were 3 (p = 0.002) and 2.8 (p = 0.007) times steeper than fluticasone propionate and salmeterol, respectively. The results highlight a more significant effect of inspiratory flow on variable dosage emission when using the Symbicort Turbuhaler compared with the Seretide Diskus.
机译：干粉吸入器释放的剂量可能与吸入流量有关。使用离体方法，即电子肺，我们测量了Seretide Diskus（沙美特罗西那福酯50 mcg;丙酸氟替卡松500 mcg）和Symbicort Turbuhaler（福莫特罗6 mcg;布地奈德200 mcg）的两种活性成分发射剂量的空气动力学特性。当使用安慰剂Seretide Diskus和安慰剂Symbicort Turbuhaler进行吸入时，从20名严重哮喘患者（平均预测PEFR为53％）中收集了电子吸入曲线。这些在相应的有源吸入器中在电子肺中回放。通过Diskus和Turbuhaler的平均（S.D.）峰值吸入流速（PIFR）分别为94.7（32.9）和76.8（26.2）l min（-1）。从电子肺的磁盘吸气曲线可知，丙酸氟替卡松和沙美特罗的平均细颗粒剂量（FPD）为标记剂量的20.4（4.8）和18.4（4.4）％。对于Turbuhaler吸入曲线，布地奈德和福莫特罗的FPD标记剂量分别为23.1（12.9）％和20.7（11.1）％。对于布地奈德和福莫特罗，FPD与PIFR之间的线性关系（p <0.001）分别比丙酸氟替卡松和沙美特罗高3（p = 0.002）和2.8（p = 0.007）。结果表明，与Seretide Diskus相比，当使用Symbicort Turbuhaler时，吸气流量对可变剂量排放的影响更大。

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