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首页> 外文期刊>Infectious diseases in obstetrics and gynecology >Spermicidal activity of the safe natural antimicrobial peptide subtilosin.
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Spermicidal activity of the safe natural antimicrobial peptide subtilosin.

机译：安全的天然抗菌肽枯草杆菌蛋白酶的杀精活性。

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Bacterial vaginosis (BV), a condition affecting millions of women each year, is primarily caused by the gram-variable organism Gardnerella vaginalis. A number of organisms associated with BV cases have been reported to develop multidrug resistance, leading to the need for alternative therapies. Previously, we reported the antimicrobial peptide subtilosin has proven antimicrobial activity against G. vaginalis, but not against the tested healthy vaginal microbiota of lactobacilli. After conducting tissue sensitivity assays using an ectocervical tissue model, we determined that human cells remained viable after prolonged exposures to partially-purified subtilosin, indicating the compound is safe for human use. Subtilosin was shown to eliminate the motility and forward progression of human spermatozoa in a dose-dependent manner, and can therefore be considered a general spermicidal agent. These results suggest subtilosin would be a valuable component in topical personal care products aimed at contraception and BV prophylaxis and treatment.
机译：细菌性阴道病（BV）是每年影响数百万妇女的疾病，主要由革兰氏可变性阴道加德纳菌引起。据报道，许多与BV病例相关的生物体会产生多药耐药性，因此需要替代疗法。先前，我们报道了抗菌肽枯草杆菌蛋白酶已被证明对阴道加德纳菌具有抗菌活性，但对被测试的乳酸杆菌的健康阴道微生物群却没有。在使用子宫颈组织模型进行组织敏感性测定后，我们确定了长时间暴露于部分纯化的枯草杆菌蛋白酶后，人类细胞仍然保持活力，表明该化合物对人类安全。枯草杆菌蛋白酶已显示出以剂量依赖的方式消除了人类精子的活力和前进进程，因此可以被认为是一般的杀精剂。这些结果表明枯草杆菌蛋白酶将是局部个人护理产品中有价值的成分，目的在于避孕，预防和治疗BV。

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