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首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >Carcinogenic and inflammatory effects of plutonium-nitrate retention in an exposed nuclear worker and beagle dogs
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Carcinogenic and inflammatory effects of plutonium-nitrate retention in an exposed nuclear worker and beagle dogs

机译：硝酸nuclear保留在裸露的核工人和比格犬中的致癌性和炎性作用

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Purpose: Plutonium-nitrate has a moderately rapid translocation rate from the lung to blood stream. Previous studies have shown an unexpected retention of soluble plutonium in the beagles and human case studied here. The inflammatory responses that may be associated with long-term exposure to ionizing radiation were characterized. These pathways include tissue injury, apoptosis, and gene expression modifications. Other protein modifications related to carcinogenesis and inflammation and the various factors that may play a role in orchestrating complex interactions which influence tissue integrity following irradiation were investigated. Materials and methods: We have examined numerous lung samples from a plutonium-exposed worker, a human control, and a variety of plutonium-exposed beagle dogs using immunohistochemistry and quantitative Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Results: The exposed human showed interstitial fibrosis in peripheral regions of the lung, but no pulmonary tumors. Beagles with similar doses were diagnosed with tumors in bronchiolo-alveolar, peripheral and sub-pleural alveolar regions of the lung. The terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay showed an elevation of apoptosis in tracheal mucosa, tumor cells, and nuclear debris in the alveoli and lymph nodes of the beagles but not in the human case. In both the beagles and human there were statistically significant modifications in the expression of Fas ligand (FASLG), B-cell lymphoma 2 (BCL2), and Caspase 3 (CASP3). Conclusions: The data suggests that FASLG, BCL2, CASP3 and apoptosis play a role in the inflammatory responses following prolonged plutonium exposure. Utilizing these unique tissues revealed which pathways are triggered following the internal deposition and long-term retention of plutonium-nitrate in a human and a large animal model.
机译：目的：硝酸P从肺到血流的迁移速度适中。先前的研究表明，在这里研究的比格犬和人的案例中，retention的残留量出乎意料。表征了可能与长期暴露于电离辐射有关的炎症反应。这些途径包括组织损伤，凋亡和基因表达修饰。研究了与癌变和炎症有关的其他蛋白质修饰，以及可能在协调复杂相互作用的各种因素中起作用，这些相互作用影响照射后的组织完整性。材料和方法：我们使用免疫组织化学和定量逆转录酶-聚合酶链反应（RT-PCR），检查了来自a接触工人，人类对照以及各种of接触比格犬的大量肺部样本。结果：暴露的人在肺的外围区域显示间质纤维化，但没有肺肿瘤。在肺支气管-肺泡，周围和胸膜下肺泡区域，诊断出具有相似剂量的小猎犬。末端脱氧核苷酸转移酶dUTP缺口末端标记（TUNEL）检测显示，比格犬的气管和淋巴结中气管粘膜，肿瘤细胞和核碎片的凋亡增加，但在人类病例中却没有。在小猎犬和人类中，Fas配体（FASLG），B细胞淋巴瘤2（BCL2）和半胱天冬酶3（CASP3）的表达都有统计学上的显着改变。结论：数据表明，S长期暴露后，FASLG，BCL2，CASP3和细胞凋亡在炎症反应中起作用。利用这些独特的组织揭示了在人类和大型动物模型中硝酸-的内部沉积和长期保留之后触发了哪些途径。

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