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首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >Modelling radiation-induced chromosome aberrations.
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Modelling radiation-induced chromosome aberrations.

机译：模拟辐射引起的染色体畸变。

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PURPOSE: To review the data and models on the induction of chromosomal aberrations by a single acute dose of radiation, then critically to assess progress that has been made so far to make a judgement about prospects for increased understanding. MATERIALS AND METHODS: Drawing upon many years of personal experience, a consistent set of data on the radiation-induced dicentric yield in human lymphocytes was produced. Other data concerning the production of complex rearrangements and the time-course of the appearance of dicentrics has also been reviewed. Three basic models have been reviewed and compared with respect to their ability to predict the judged dose-effect relationships as well as the time-course and complexity of the aberration production. CONCLUSIONS: None of the three basic models alone can explain adequately all of the available data. A combination of the models has succeeded to a greater extent, but there is still no complete agreement. The major reason for the discrepancy between the measured yield curves and their predictions lies in the variation of the quadratic term in the dose-response relationship with increasing linear energy transfer. Further experimental work is required to resolve this.
机译：目的：回顾一下单次急性剂量辐射诱发染色体畸变的数据和模型，然后批判性地评估迄今为止已取得的进展，以判断对增进理解的前景。材料和方法：借鉴多年的个人经验，得出了一系列有关辐射诱导的人淋巴细胞双着丝粒产量的一致数据。还审查了其他有关复杂重排产生和双着丝粒出现的时间过程的数据。对三种基本模型进行了回顾和比较，它们可以预测所判断的剂量效应关系以及像差产生的时程和复杂性。结论：仅这三个基本模型都无法充分解释所有可用数据。这些模型的组合已在更大程度上取得了成功，但仍未达成完全共识。所测得的产率曲线与其预测之间存在差异的主要原因在于，随着线性能量传递的增加，剂量-响应关系中的二次项会发生变化。需要进一步的实验工作来解决这个问题。

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