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首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >Alterations in water and electrolyte absorption in the rat colon following neutron irradiation: influence of neutron component and irradiation dose.
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Alterations in water and electrolyte absorption in the rat colon following neutron irradiation: influence of neutron component and irradiation dose.

机译：中子辐照后大鼠结肠中水和电解质吸收的变化：中子成分和辐照剂量的影响。

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Purpose: To study the absorptive function of rat colon following whole-body exposure to neutron irradiation, either to the same total dose with varying proportion of neutrons or to the same neutron proportion with an increasing irradiation dose. Materials and methods: Different proportions of neutron irradiation were produced from the reactor SILENE using a fissile solution of uranium nitrate (8, 47 and 87% neutron). Water and electrolyte fluxes were measured in the rat in vivo under anaesthesia by insertion into the descending colon of an agarose gel cylinder simulating the faeces. Functional studies were completed by histological analyses. In the first set of experiments, rats received 3.8 Gy with various neutron percentages and were studied from 1 to 14 days after exposure. In the second set of experiments, rats were exposed to increasing doses of irradiation (1-4Gy) with a high neutron percentage (87%n) and were studied at 4 days after exposure. Results and conclusions: The absorptive capacity of rat colon was diminished by irradiation at 3-5 days, with a nadir at 4 days. The results demonstrate that an increase in the neutron proportion is associated with an amplification of the effects. Furthermore, a delay in the re-establishment of normal absorption was observed with the high neutron proportion (87%n). A dose-dependent reduction of water absorption by rat colon was also observed following neutron irradiation (87%n), with a 50% reduction at 3 Gy. Comparison of this dose-effect curve with the curve obtained following gamma (60)Co-irradiation indicates an RBE of 2.2 for absorptive colonic function in rat calculated at 4 days after exposure.
机译：目的：研究全身暴露于中子辐照后大鼠结肠的吸收功能，或者以相同的总剂量，不同的中子比例或以相同的中子比例，随着辐照剂量的增加。材料和方法：使用易裂变硝酸铀溶液（8％，47％和87％中子）从反应堆SILENE产生不同比例的中子辐照。通过在大鼠体内麻醉下通过将其插入模拟粪便的琼脂糖凝胶圆柱体的下降结肠中来测量水和电解质通量。功能研究通过组织学分析完成。在第一组实验中，大鼠接受了3.8 Gy的中子百分数，并在暴露后1到14天进行了研究。在第二组实验中，将大鼠暴露于高中子百分比（87％n）的增加剂量的辐射（1-4Gy）中，并在暴露后4天进行研究。结果与结论：3-5天辐照降低大鼠结肠的吸收能力，4天达到最低点。结果表明，中子比例的增加与影响的扩大有关。此外，在中子比例高（87％n）的情况下，观察到恢复正常吸收的延迟。在中子辐照后，还观察到大鼠结肠对水的吸收呈剂量依赖性降低（87％n），在3 Gy时降低50％。将该剂量效应曲线与在γ（60）共辐照后获得的曲线进行比较，表明在暴露后4天计算的大鼠吸收性结肠功能的RBE为2.2。

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