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首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >Evaluation of risk factors for lung tumour induction in rats exposed to either NpO(2) or PuO(2) aerosols.
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Evaluation of risk factors for lung tumour induction in rats exposed to either NpO(2) or PuO(2) aerosols.

机译：评价暴露于NpO（2）或PuO（2）气溶胶的大鼠中肺肿瘤诱发的危险因素。

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PURPOSE: To compare the incidence of each lung tumour type after inhalation exposure of rats to either NpO(2) or industrial PuO(2) aerosols, which have a similar size. MATERIALS AND METHODS: Male Sprague-Dawley rats were exposed once and followed during their whole life span. At the end of their life, the whole lungs were fixed, embedded and cut into thin sections for histological analysis. The presence of tumours was evaluated on three distinct levels of the lobes for phenotype determination to establish dose-effect relationships. RESULTS: In the range of lung doses studied (0.05 to more than 50 Gy), the general trend was an increased frequency of all types of tumours after inhalation exposure to neptunium compared with plutonium. The linearity of the lower part of the dose-effect relationships for all malignant lung tumours leads to the conclusion that NpO(2) is 3.3-fold more carcinogenic than PuO(2). CONCLUSIONS: According to a linear extrapolation of the data on malignant lung tumour incidence collected among all studies reported on actinide oxide carcinogenesis, the risk of lung tumour appears to vary over a factor of about 10 depending on the nature and/or size of the aerosol. This variation has to be taken into account for a realistic assessment of tumour risk.
机译：目的：比较大鼠吸入具有相似大小的NpO（2）或工业PuO（2）气溶胶后，每种肺肿瘤类型的发生率。材料与方法：将雄性Sprague-Dawley大鼠暴露一次，并在其整个寿命中对其进行跟踪。在生命的尽头，将整个肺部固定，包埋并切成薄片以进行组织学分析。在叶的三个不同水平上评估肿瘤的存在以进行表型测定，以建立剂量-效应关系。结果：在研究的肺剂量范围内（0.05至大于50 Gy），总体趋势是与exposure相比，吸入exposure暴露后所有类型肿瘤的发生率增加。所有恶性肺肿瘤的剂量效应关系的下部呈线性关系，得出的结论是NpO（2）的致癌性比PuO（2）高3.3倍。结论：根据关于act系元素氧化物致癌作用的所有研究报告中收集的恶性肺肿瘤发病率数据的线性推论，根据气溶胶的性质和/或大小，患肺肿瘤的风险似乎变化了约10倍。 。为了实际评估肿瘤风险，必须考虑这种变化。

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