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首页> 外文期刊>International Journal of Radiation Oncology, Biology, Physics >Comparison of treatment outcome between breast-conservation surgery with radiation and total mastectomy without radiation in patients with one to three positive axillary lymph nodes.
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Comparison of treatment outcome between breast-conservation surgery with radiation and total mastectomy without radiation in patients with one to three positive axillary lymph nodes.

机译：1-3例腋窝淋巴结转移阳性患者行保乳手术加放疗与不加放射线全乳切除的治疗效果比较。

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PURPOSE: To test the difference in treatment outcome between breast-conservation surgery with radiation and total mastectomy without radiation, to evaluate the benefits of adjuvant radiotherapy in patients with one to three positive axillary lymph nodes. METHODS AND MATERIALS: Using the Severance Hospital Breast Cancer Registry, we divided the study population of T1, T2 and one to three axillary node-positive patients into two groups: breast-conservation surgery with radiation (BCS/RT) and total mastectomy without radiation (TMo-RT). Data related to locoregional recurrence, distant recurrence, and death were collected, and survival rates were calculated. RESULTS: The study population consisted of 125 patients treated with BCS/RT and 365 patients treated with TMo-RT. With a median follow-up of 68.4 months, the 10-year locoregional recurrence-free survival rate with BCS/RT and TMo-RT was 90.5% and 79.2%, respectively (p = 0.056). The 10-year distant recurrence-free survival rate was 78.8% for patients treated with BCS/RT vs. 68.0% for those treated with TMo-RT (p = 0.012). The 10-years overall survival rate for patients treated with BCT/RT and TMo-RT was 87.5% and 73.9%, respectively (p = 0.035). After multivariate analysis, patients treated with BCT/RT had better distant recurrence-free survival (hazard ratio [HR], 0.527; 95% confidence interval [CI], 0.297-0.934; p = 0.028), with improving locoregional recurrence-free survival (HR, 0.491; 95% CI, 0.231-1.041; p = 0.064) and overall survival trend (HR, 0.544; 95% CI, 0.277-1.067; p = 0.076). CONCLUSIONS: This study provides additional evidence that adjuvant radiation substantially reduces local recurrence, distant recurrence, and mortality for patients with one to three involved nodes.
机译：目的：检验在保留乳房的放射治疗和不进行放射的全乳房切除术之间的治疗结果的差异，以评估辅助放射疗法在腋窝淋巴结阳性的患者中的一至三个的疗效。方法和材料：使用Severance医院乳腺癌注册中心，将研究的T1，T2和一到三名腋窝淋巴结转移阳性的患者分为两组：放射线保乳术（BCS / RT）和无放射线全乳切除术（TM /无RT）。收集与局部复发，远处复发和死亡相关的数据，并计算存活率。结果：研究人群包括125名接受BCS / RT治疗的患者和365名接受TM / no-RT治疗的患者。中位随访时间为68.4个月，使用BCS / RT和TM / no-RT的10年局部无复发生存率分别为90.5％和79.2％（p = 0.056）。 BCS / RT治疗的患者10年远距离无复发生存率为78.8％，而TM / no-RT治疗的患者为68.0％（p = 0.012）。 BCT / RT和TM / no-RT治疗的患者10年总生存率分别为87.5％和73.9％（p = 0.035）。经过多因素分析后，接受BCT / RT治疗的患者具有更好的远距离无复发生存率（危险比[HR]为0.527; 95％置信区间[CI]为0.297-0.934; p = 0.028），并改善了局部无复发生存率（HR，0.491; 95％CI，0.231-1.041; p = 0.064）和总体生存趋势（HR，0.544; 95％CI，0.277-1.067; p = 0.076）。结论：这项研究提供了额外的证据，表明辅助放射线可显着降低具有一到三个受累淋巴结的患者的局部复发，远处复发和死亡率。

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