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首页> 外文期刊>International Journal of Probiotics & Prebiotics >The effects of probiotic combination Lactobacillus rhamnosus GG and Lactobacillus rhamnosus LC705 in cytokine and chemokine response in human macrophages.
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The effects of probiotic combination Lactobacillus rhamnosus GG and Lactobacillus rhamnosus LC705 in cytokine and chemokine response in human macrophages.

机译：益生菌联合鼠李糖乳杆菌GG和鼠李糖乳杆菌LC705对人巨噬细胞的细胞因子和趋化因子反应的影响。

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摘要

This study sought to determine whether the combination of Lactobacillus rhamnosus GG (GG) and L. rhamnosus Lc705 (Lc705) enhances the innate immune responses of human monocyte-derived macrophages to a greater extent that either of the 2 bacteria when used alone. In addition, effects of the combination were compared to those of Lactococcus lactis ssp. cremoris ARH74 (ARH74). Human macrophages were stimulated with viable GG, Lc705 and ARH74 for 24 h, and production of TNF alpha, IL-1 beta, IL-6, IL-10 and IL-12, as well as the chemokines, CCL2/monocyte chemoattractant protein-1 (MCP-1) and CXCL10/IFN-inducible protein 1 (IP-10). The combination of GG and Lc705 enhanced the IL-1 beta response to a greater extent than Lc705 alone and induced TNF- alpha, IL-1 beta, IL-6 and IL-10 more strongly than ARH74. However, ARH74 was the most potent inducer of chemokines MCP-1 and IP-10.
机译：这项研究试图确定鼠李糖乳杆菌GG（GG）和L的组合。鼠李糖Lc705（Lc705）增强了人类单核细胞衍生的巨噬细胞的先天免疫反应，其程度比单独使用时两种细菌中的任何一种都大。另外，将该组合的效果与乳酸乳球菌（Lactococcus lactis）ssp的效果进行了比较。 cremoris ARH74（ARH74）。人类巨噬细胞用可行的GG，Lc705和ARH74刺激24小时，并产生TNFα，IL-1β，IL-6，IL-10和IL-12以及趋化因子，CCL2 /单核细胞趋化蛋白- 1（MCP-1）和CXCL10 / IFN诱导蛋白1（IP-10）。 GG和Lc705的组合比单独的Lc705更大程度地增强了IL-1β应答，并且比ARH74更强烈地诱导了TNF-α，IL-1β，IL-6和IL-10。但是，ARH74是趋化因子MCP-1和IP-10的最强诱导剂。

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