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首页> 外文期刊>International journal of sports medicine >The COL12A1 and COL14A1 Genes and Achilles Tendon Injuries.
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The COL12A1 and COL14A1 Genes and Achilles Tendon Injuries.

机译：COL12A1和COL14A1基因和跟腱损伤。

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摘要

Genes encoding for tenascin C and a subunit of type V collagen have previously been reported to be associated with Achilles tendon injuries. Types XII and XIV collagen may be involved in similar biological processes as these proteins in tendons. The aim of this study was therefore to test the association between polymorphisms within COL12A1 and COL14A1 and Achilles tendon injuries. Restriction fragment length polymorphism (RFLP) analysis was used to identify the relative frequencies of two polymorphisms within each of the COL12A1 and COL14A1 genes within 137 subjects with clinical symptoms of Achilles tendon injuries, consisting of 93 with Achilles tendinopathy and 44 with Achilles tendon rupture, and 131 asymptomatic control subjects. No statistically significant differences were identified in the genotype, allele or haplotype distributions between the affected and control subjects. The findings from this study suggest that although COL12A1 and COL14A1 are involved in similar biological processes as TNC and COL5A1, the polymorphisms tested are not associated with clinical symptoms of Achilles tendon injury within the investigated population.
机译：先前已经报道了编码腱生蛋白C和V型胶原蛋白亚基的基因与跟腱损伤有关。 XII和XIV型胶原蛋白可能与肌腱中的这些蛋白类似的生物过程。因此，本研究的目的是检验COL12A1和COL14A1内的多态性与跟腱损伤之间的关联。使用限制性片段长度多态性（RFLP）分析来确定137例具有跟腱损伤临床症状的受试者中每个COL12A1和COL14A1基因内两个多态性的相对频率，其中包括93例跟腱病和44例跟腱破裂， 131名无症状对照受试者。在受影响和对照受试者之间的基因型，等位基因或单倍型分布中未发现统计学上的显着差异。这项研究的结果表明，尽管COL12A1和COL14A1与TNC和COL5A1参与相似的生物学过程，但所测试的多态性与被调查人群中的跟腱损伤的临床症状无关。

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