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首页> 外文期刊>British journal of neurosurgery >Giant pituitary adenomas: clinical characteristics and surgical results.
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Giant pituitary adenomas: clinical characteristics and surgical results.

机译：垂体大腺瘤：临床特点及手术效果。

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Although most pituitary neoplasms are benign, some grow rapidly, spreading to extrasellar tissues. Definition of these 'giant' pituitary adenomas (PAs) is not clear. In order to clarify this question, we studied all pituitary macroadenomas operated in our hospital during the last 20 years, differentiating those with diameter > or = 3 cm (n = 43) and attempting to identify their typical features and prognosis. The reason for consultation was local in 58.3% of giant PAs, hormonal in 22.9% and tumour recurrence in 16.7%. Surgery was performed via a trans-sphenoidal approach in 92.5% of cases and succeeded in completely removing the tumour in only 27% of cases. In conclusion, we found that giant PAs are not a special type but the extreme case in the gradient of invasiveness of tumours of adenohypophyseal origin. They are characterized by a higher frequency of neuro-ophthalmological symptoms and hormonal deficits, and poorer response to surgical treatment.
机译：尽管大多数垂体瘤是良性的，但有些会迅速生长，并扩散到巩膜外组织。这些“巨大的”垂体腺瘤（PAs）的定义尚不清楚。为了澄清这个问题，我们研究了过去20年间在我院手术的所有垂体大腺瘤，以区分直径大于或等于3 cm（n = 43）的垂体腺瘤，并试图确定其典型特征和预后。会诊的原因是巨大的PA中有58.3％是局部的，激素是22.9％，肿瘤复发的是16.7％。 92.5％的病例通过经蝶骨入路进行手术，仅27％的病例成功切除了肿瘤。总而言之，我们发现巨PAs不是一种特殊类型，而是腺垂体起源肿瘤浸润度梯度的极端情况。它们的特征是神经眼科症状和激素缺乏症的频率较高，并且对手术治疗的反应较差。

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