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Neural membrane field effects in a cytoskeleton corral: Microdomain regulation of impulse propagation

机译:细胞骨架皮质中的神经膜场效应:脉冲传播的微区调节。

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This article proposes that electrostatic interaction between transiently polarized neural-membrane ethenes and charged residues of an unfolded ion-channel protein regulate channel closing and electrical signaling in neurons. Field effects are confined by a cytoskeleton corral that gates movement of membrane lipids from one corralled region to another. Cytoskeleton gating permits stepwise changes in the concentration of unsaturated lipids and thereby modulates ion-channel activity. The system is hypothesized to operate at axonal branch points where impulse conduction has a low safety factor. Throughout the discussion the A-current delayed-rectifier potassium channel is used as an example. Implications of the model for molecular networks are briefly discussed. (C) 2004 Wiley Periodicals, Inc.
机译:本文提出瞬态极化的神经膜乙烯醚和未折叠的离子通道蛋白的带电残基之间的静电相互作用调节神经元中的通道关闭和电信号传导。场效应受到细胞骨架围栏的限制,后者控制着膜脂从一个围栏区域到另一围栏区域的运动。细胞骨架门控可逐步改变不饱和脂质的浓度,从而调节离子通道活性。假设该系统可在脉冲传导安全系数较低的轴突分支点运行。在整个讨论中,以A电流延迟整流器钾离子通道为例。简要讨论了该模型对分子网络的影响。 (C)2004年Wiley Periodicals,Inc.

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