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首页> 外文会议>World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food Environmental Technologies >Sensitivity of Cells to Nanosecond Pulsed Electric Fields is Dependent on Membrane Lipid Microdomains
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Sensitivity of Cells to Nanosecond Pulsed Electric Fields is Dependent on Membrane Lipid Microdomains

机译：细胞对纳秒脉冲电场的敏感性取决于膜脂质微摩粉

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摘要

Previous work from our laboratory demonstrated significant nanopore formation in cellular membranes following exposure of cells to nanosecond pulsed electric fields (nsPEF). We hypothesize that the sensitivity of cells to nsPEF is dependent on the properties of the plasma membrane, including lipid microdomains. Results show that depletion of membrane cholesterol increases the sensitivity of cells to nsPEF. Cholesterol depletion increases the permeability of cells to small molecules, including propidium iodide and calcium, at shorter nsPEF exposures. In contrast, depletion of caveolin, an important protein component of membrane lipid microdomains, renders the cells less sensitive to nsPEF. The results of the current study suggest that plasma membrane cholesterol and proteins are important determinants in the cellular response to nsPEF.
机译：我们实验室的以前的工作在细胞暴露于纳秒脉冲电场（NPEF）后，在细胞膜中表现出显着的纳米孔形成。我们假设细胞对NPEF的敏感性取决于质膜的性质，包括脂质微摩擦。结果表明，膜胆固醇的耗竭会使细胞对NPSF的敏感性增加。胆固醇耗竭在短的NPSPEF暴露中增加了细胞对小分子的渗透率，包括碘化钛和钙。相反，Caveolin的耗尽，膜脂质微瘤的重要蛋白质组分，使细胞对NPSF敏感。目前的研究结果表明，质膜胆固醇和蛋白质是对NPSPEF细胞反应中的重要决定因素。

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