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首页> 外文期刊>Advances in neonatal care: official journal of the National Association of Neonatal Nurses >Use of Benzodiazepines as Anxiolytics in Neonates Are We There Yet?
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Use of Benzodiazepines as Anxiolytics in Neonates Are We There Yet?

机译：新生儿使用苯二氮卓类抗焦虑药我们还在那里吗？

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Few controlled trials exist to demonstrate the efficacy and the risks of pharmacologic agents used in treating pediatric, and more specifically neonatal patients. It is not different for the central nervous system altering class of drugs, benzodiazepines (BZDs). Little information is known about the long-term effects of BZDs use in neonates as anxiolytics and sedatives causing trepidation with their use in the clinical setting. Insufficient data related to the use of BZDs result in a lack of clear recommendations to guide caregivers at the bedside on the safest administration patterns to avoid long-term adverse effects. However, caring for ill neonates, in particular surgical patients and infants requiring prolonged hospitalizations, necessitates the use of these agents. A literature search within the electronic database, PubMed, of English language, full-text articles published between 2007 and 2012 was undertaken to determine the state of the science regarding the use of BZDs in neonates. These medications cause unwanted effects in neonates with immature hepatic function (primary site of metabolism) and during a developmental period of tremendous neuroplasticity. It benefits caregivers to recognize the need for improved monitoring of stress experienced by infants in the NICU and understand the impact of prolonged agitation and subacute pain on infant development.
机译：很少有对照试验能够证明药物治疗小儿，尤其是新生儿患者的功效和风险。中枢神经系统改变药物类别苯并二氮杂B（BZDs）并没有什么不同。关于BZDs在新生儿中作为抗焦虑药和镇静剂在临床环境中使用引起惊恐的长期影响知之甚少。有关使用BZD的数据不足，导致缺乏明确的建议来指导床旁的护理人员以最安全的给药方式避免长期不良反应。但是，照顾生病的新生儿，特别是外科手术患者和需要长期住院的婴儿，必须使用这些药物。我们在电子数据库PubMed中搜索了2007年至2012年之间发布的英语英语全文文章，以确定新生儿使用BZD的科学状况。这些药物会对肝功能不成熟的新生儿（代谢的主要部位）以及发生巨大神经可塑性的发育期造成不良影响。照顾者认识到需要更好地监测新生儿重症监护病房（NICU）中的婴儿的压力，并了解长时间的躁动和亚急性疼痛对婴儿发育的影响，这使护理人员受益。

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