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首页> 外文期刊>British Poultry Science >Effects of age and strain on the expression of leptin receptor, neuropeptide Y and pro-opiomelanocortin in the hypothalamus of young chickens
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Effects of age and strain on the expression of leptin receptor, neuropeptide Y and pro-opiomelanocortin in the hypothalamus of young chickens

机译:年龄和品系对幼小鸡下丘脑瘦素受体,神经肽Y和opiomelanocortin表达的影响

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摘要

1. An experiment was conducted to study changes in the expression of the hypothalamic leptin receptor, neuropeptide Y (NPY) and proopiomelanocortin (POMC) with age during the early neonatal period in two different strains of chickens: Beijing-You (BY) and Arbor Acres (AA). 2. Compared with BY chickens, AA chickens ate more, and grew faster. Hypothalamic NPY concentrations of both strains increased with age until d 7 followed by a decline. Hypothalamic NPY of BY chickens on d 7 was lower than in AA chickens at the same age. 3. No difference with age was observed in hypothalamic -melanocyte-stimulating hormone (-MSH) of BY chickens, while hypothalamic -MSH in AA chickens on d 0 was higher than on the other days. Compared with AA chickens, BY chickens showed lower hypothalamic -MSH on d 0. 4. Similar developmental changes between two strains were observed in the expression of leptin receptor, NPY or POMC genes in the hypothalamus. Hypothalamic mRNA of leptin receptor on d 0 was higher than on d 1 and 7. Unlike NPY, hypothalamic NPY mRNA on d 0 was higher than on the other days. 5. Hypothalamic POMC mRNA decreased gradually with age until 7 d followed by a slight increase. 6. The results showed that the developmental changes of hypothalamic signal molecules varied with age and strain. NPY, -MSH and leptin receptor might be involved in the early programming of feed intake in newly hatched chickens.
机译:1.进行了一项实验,以研究新生儿早期期间下丘脑瘦素受体,神经肽Y(NPY)和丙型黑皮皮质激素(POMC)在两种不同品系的鸡中的表达变化:北京优(BY)和阿伯英亩(AA)。 2.与BY鸡相比,AA鸡吃得更多,并且生长更快。两种菌株的下丘脑NPY浓度均随着年龄的增长而增加,直到d 7以后才下降。第7天的BY鸡的下丘脑NPY低于同龄的AA鸡。 3. BY鸡的下丘脑-黑素细胞刺激激素(-MSH)在年龄上未见差异,而第0天的AA鸡的下丘脑-MSH则高于其他几天。与AA鸡相比,BY鸡在d 0时表现出较低的下丘脑-MSH。4.在下丘脑中,瘦素受体,NPY或POMC基因的表达在两个毒株之间观察到相似的发育变化。 d 0瘦素受体的下丘脑mRNA高于d 1和d7。与NPY不同,d 0的下丘脑NPY mRNA高于其他几天。 5.下丘脑POMC mRNA随着年龄的增长而逐渐降低,直至7 d,然后略有增加。 6.结果表明,下丘脑信号分子的发育变化随年龄和应变而变化。 NPY,-MSH和瘦蛋白受体可能与新孵化鸡的采食量的早期编程有关。

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