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首页> 外文期刊>International Journal of Neuroscience >Motor unit number estimation (mune) as a quantitative measure of disease progression and motor unit reorganization in amyotrophic lateral sclerosis.
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Motor unit number estimation (mune) as a quantitative measure of disease progression and motor unit reorganization in amyotrophic lateral sclerosis.

机译：运动单位数量估计（月龄），作为肌萎缩性侧索硬化症中疾病进展和运动单位重组的定量度量。

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摘要

Motor Unit Number Estimation (MUNE), a technique allowing to estimate the number of functioning Motor Units (MU) in single muscles, was used to score the disease's severity and progression rate in a group of 58 patients with Amyotrophic Lateral Sclerosis (ALS). All patients underwent MUNE in the abductor digiti minimi (ADM) muscle during the diagnostic work-up (T0), after three (T1) and six (T2) months. A significant loss [p < .001] of MU and a decrease [p < .001] of the maximal M wave area at T0 was found, whereas mean step area was increased [p < .001]. During the follow-up (T1 and T2), MU loss continued, maximal M wave decreased, and mean step area increased significantly. The results confirm that MUNE is a suitable tool to quantify the pathological changes in MU in patients with ALS.
机译：运动单位数估计（MUNE）是一项允许估计单个肌肉功能性运动单位（MU）数量的技术，用于对58例肌萎缩性侧索硬化症（ALS）患者的疾病严重程度和进展速度进行评分。在诊断检查（T0）的三个月（T1）和六个月（T2）之后，所有患者均在数位小指外展肌（ADM）中进行了MUNE。发现在T0时MU明显损失[p <.001]，最大M波面积减小[p <.001]，而平均步幅增加[p <.001]。在随访期间（T1和T2），MU丢失持续，最大M波减少，平均步伐面积显着增加。结果证实，MUNE是量化ALS患者MU病理变化的合适工具。

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