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首页> 外文期刊>International Journal of Neuroscience >Patterns of FOS expression in the spinal cord and periaqueductal grey matter of 6OHDA-lesioned rats.
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Patterns of FOS expression in the spinal cord and periaqueductal grey matter of 6OHDA-lesioned rats.

机译：6OHDA损伤大鼠的脊髓和导水管周围灰质中FOS表达的模式。

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摘要

A less well-known feature of Parkinson disease is that up to 40% of patients experience distinct sensory disturbances, including hyperalgesia and chronic pain. There is a limited understanding of the neural mechanisms that generate these symptoms, however. This study explores the patterns of Fos expression (a well-known marker for changes in cell activity) in the spinal cord and periaqueductal grey matter (PaG), two major sensory (nociceptive) centers, of hemiParkinsonian rats. The medial forebrain bundle (mfb; major tract carrying dopaminergic nigrostriatal axons) was injected with either 6OHDA or saline (controls). A week later, some rats were subjected to mechanical stimulation (pinching) of the hindpaw for 2 h, whereas others received no stimulation. Thereafter, brains were processed using routine tyrosine hydroxylase (marker for dopaminergic cells) or Fos immunocytochemistry. In the PaG, there were many more Fos(+) cells in the 6OHDA-lesioned than in the Control group, in both the stimulation and,in particular, the non-stimulation cases. In the spinal cord, there were also more Fos(+) cells in the 6OHDA-lesioned than in the Control group, but in the stimulation cases only. Overall, the results show distinct changes in Fos expression in the spinal cord and PaG of 6OHDA-lesioned rats, suggesting a substrate for some of the abnormal sensory (nociceptive) circuits that may be evident in parkinsonian cases.
机译：帕金森病的一个鲜为人知的特征是，多达40％的患者会经历明显的感觉障碍，包括痛觉过敏和慢性疼痛。但是，对产生这些症状的神经机制的认识有限。这项研究探索了半帕金森氏大鼠的两个主要感觉（伤害感受）中心的脊髓和水管周围灰质（PaG）中Fos表达的模式（一种众所周知的细胞活性变化标记）。前内侧束（mfb;携带多巴胺能黑质纹状体轴突的大束）注射6OHDA或生理盐水（对照组）。一周后，一些大鼠受到后爪的机械刺激（捏）2小时，而另一些则没有受到刺激。之后，使用常规酪氨酸羟化酶（多巴胺能细胞的标志物）或Fos免疫细胞化学处理大脑。在刺激和特别是非刺激的情况下，在PaOH中6OHDA病变的Fos（+）细胞比对照组要多。与对照组相比，在6OHDA病变的脊髓中，Fos（+）细胞也更多，但仅在刺激情况下。总体而言，结果表明6OHDA损伤大鼠的脊髓和PaG中Fos表达发生明显变化，这表明某些异常的感觉（伤害感受）回路的底物可能在帕金森病病例中很明显。

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