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首页> 外文期刊>International Journal of Neuroscience >Evaluation of serum IgG subclass concentrations in myasthenia gravis patients.
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Evaluation of serum IgG subclass concentrations in myasthenia gravis patients.

机译：重症肌无力患者血清IgG亚类浓度的评估。

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摘要

Myasthenia gravis (MG) is an autoimmune disease characterized by preferential production of a variety of autoantibodies. We aimed to investigate serum IgG subclass levels in MG patients. Serum IgG subclass levels from 85 MG patients were determined by the immunonephelometric assay. The median levels of IgG1, IgG2, IgG3, and IgG4 in MG patients were 7,360 mg/L, 5,750 mg/L, 860 mg/L, and 340 mg/L, respectively. When compared with normal controls, a significant increase of IgG1 (p = .000), IgG2 (p = .000), IgG3 (p = .000), and IgG4 (p = .029) was observed in MG patients. When the MG patients were divided into different groups, higher levels of IgG1 and IgG3 were observed in anti-AChR antibody positive group. Also, the level of IgG1 was statistically higher in female than that in male, and the level of IgG4 in late-onset group was significantly higher than that in early-onset group. There was a significant inverse correlation between the concentrations of IgG2 and IgG4 and disease duration. Our data suggested that IgG subclasses were preferentially produced during the process of MG, which could enable us a better understanding of MG.
机译：重症肌无力（MG）是一种自身免疫性疾病，其特征是优先产生各种自身抗体。我们旨在研究MG患者的血清IgG亚类水平。通过免疫比浊法测定了来自85名MG患者的血清IgG亚类水平。 MG患者的IgG1，IgG2，IgG3和IgG4的中位水平分别为7,360 mg / L，5,750 mg / L，860 mg / L和340 mg / L。与正常对照组相比，在MG患者中观察到IgG1（p = .000），IgG2（p = .000），IgG3（p = .000）和IgG4（p = .029）显着增加。当将MG患者分为不同的组时，在抗AChR抗体阳性组中观察到更高的IgG1和IgG3水平。而且，女性的IgG1水平在统计学上高于男性，并且晚发组的IgG4水平显着高于早发组。 IgG2和IgG4的浓度与疾病持续时间之间呈显着负相关。我们的数据表明，IgG亚类在MG过程中优先产生，这可以使我们对MG有更好的了解。

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