• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of toxicology >Amended final report on the safety assessment of glyceryl dilaurate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl diricinoleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl distearate, glyceryl palmitate lactate, glyceryl stearate citrate, glyceryl stearate lactate, and glyceryl stearate succinate.
【24h】

Amended final report on the safety assessment of glyceryl dilaurate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl diricinoleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl distearate, glyceryl palmitate lactate, glyceryl stearate citrate, glyceryl stearate lactate, and glyceryl stearate succinate.

机译：关于二月桂酸甘油酯，二花生酸甘油酯，二山hen酸甘油酯，二硬脂酸甘油酯，二羟基硬脂酸甘油酯，二异棕榈酸甘油酯，二异硬脂酸甘油酯，二亚油酸甘油酯，二硬脂酸甘油酯，二甘油酸甘油酯，二甘油酸甘油酯的安全性评估的最终报告修订本棕榈酸甘油酯乳酸酯，硬脂酸甘油酯柠檬酸酯，硬脂酸甘油酯乳酸酯和硬脂酸甘油酯琥珀酸酯。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Glyceryl Dilaurate, Glyceryl Diarachidate, Glyceryl Dibehenate, Glyceryl Dierucate, Glyceryl Dihydroxystearate, Glyceryl Diisopalmitate, Glyceryl Diisostearate, Glyceryl Dilinoleate, Glyceryl Dimyristate, Glyceryl Dioleate, Glyceryl Diricinoleate, Glyceryl Dipalmitate, Glyceryl Dipalmitoleate, Glyceryl Distearate, Glyceryl Palmitate Lactate, Glyceryl Stearate Citrate, Glyceryl Stearate Lactate, and Glyceryl Stearate Succinate are diacylglycerols (also known as diglycerides or glyceryl diesters) that function as skin conditioning agents - emollients in cosmetics. Only Glyceryl Dilaurate (up to 5%), Glyceryl Diisostearate (up to 43%), Glyceryl Dioleate (up to 2%), Glyceryl Distearate (up to 7%), and Glyceryl Stearate Lactate (up to 5%) are reported to be in current use. Production proceeds from fully refined vegetable oils, which are further processed using hydrogenation and fractionation techniques, and the end products are produced by reacting selected mixtures of the partly hydrogenated, partly fractionated oils and fats with vegetable-derived glycerine to yield partial glycerides. In the final stage of the production process, the products are purified by deodorization, which effectively removes pesticide residues and lower boiling residues such as residues of halogenated solvents and aromatic solvents. Diglycerides have been approved by the Food and Drug Administration (FDA) for use as indirect food additives. Nominally, these ingredients are 1,3-diglycerides, but are easily isomerized to the 1,2-diglycerides form. The 1,3-diglyceride isomer is not a significant toxicant in acute, short-term, subchronic, or chronic animal tests. Glyceryl Dilaurate was a mild primary irritant in albino rabbits, but not a skin sensitizer in guinea pig maximization tests. Diacylglycerol Oil was not genotoxic in the Ames test, in mammalian Chinese hamster lung cells, or in a rodent bone marrow micronucleus assay. An eye shadow containing 1.5% Glyceryl Dilaurate did not induce skin irritation in a single insult patch test, but mild skin irritation reactions to a foundation containing the same concentration were observed. A trade mixture containing an unspecified concentration of Glyceryl Dibehenate did not induce irritation or significant cutaneous intolerance in a 48-h occlusive patch test. In maximization tests, neither an eye shadow nor a foundation containing 1.5% Glyceryl Dilaurate was a skin sensitizer. Sensitization was not induced in subjects patch tested with 50% w/w Glyceryl Dioleate in a repeated insult, occlusive patch test. Glyceryl Palmitate Lactate (50% w/v) did not induce skin irritation or sensitization in subjects patch tested in a repeat-insult patch test. Phototoxicity or photoallergenicity was not induced in healthy volunteers tested with a lipstick containing 1.0% Glyceryl Rosinate. Two diacylglycerols, 1-oleoyl-2-acetoyl-sn-glycerol and 1,2-dipalmitoyl-sn-glycerol, did not alter cell proliferation (as determined by DNA synthesis) in normal human dermal fibroblasts in vitro at doses up to 10 microg/ml. In the absence of initiation, Glyceryl Distearate induced a moderate hyperplastic response in randomly bred mice of a tumor-resistant strain, and with 9,10-dimethyl-1,2-benzanthracene (DMBA) initiation, an increase in the total cell count was observed. In a glyceryl monoester study, a single application of DMBA to the skin followed by 5% Glyceryl Stearate twice weekly produced no tumors, but slight epidermal hyperplasia at the site of application. Glyceryl Dioleate induced transformation in 3-methylcholanthrene-initiated BALB/3T3 A31-1-1 cloned cells in vitro. A tumor-promoting dosing regimen that consisted of multiple applications of 10 mumol of a 1,2-diacylglycerol (sn-1,2-didecanoylglycerol) to female mice twice daily for 1 week caused more than a 60% decrease in protein kinase C (PKC) activity and marked epidermal hyperplasia. Applications of 10 micromol sn-1,2-didecanoylglycerol twice weekly for 1 week caused a decrease i
机译：二月桂酸甘油酯，甘油Diarachidate，甘油二山嵛酸酯，甘油Dierucate，甘油Dihydroxystearate，甘油Diisopalmitate，异硬脂酸甘油酯，甘油亚油酸酯，甘油肉豆蔻，二油酸甘油酯，甘油Diricinoleate，甘油二棕榈酸酯，甘油Dipalmitoleate二硬脂酸甘油酯，甘油棕榈酸酯乳酸，甘油硬脂酸柠檬酸，硬脂酸甘油酯和琥珀酸硬脂酸甘油酯是二酰基甘油（也称为甘油二酸酯或甘油二酯），可作为皮肤调理剂-化妆品中的润肤剂。据报道只有二月桂酸甘油酯（最高5％），甘油二异硬脂酸甘油酯（最高43％），甘油二油酸酯（最高2％），甘油二硬脂酸甘油酯（最高7％）和甘油硬脂酸甘油酯（最高5％）目前正在使用。生产过程是从完全精制的植物油中进行的，然后使用氢化和分馏技术对其进行进一步处理，最终产品是通过将部分氢化的，部分分馏的油脂和脂肪的选定混合物与源自植物的甘油反应生成部分甘油酯来生产的。在生产过程的最后阶段，产品通过除臭纯化，可有效去除农药残留物和较低沸点的残留物，例如卤化溶剂和芳族溶剂的残留物。甘油二酸酯已获得美国食品药品管理局（FDA）的批准，可用作间接食品添加剂。这些成分名义上是1，3-甘油二酸酯，但是很容易异构化成1，2-甘油二酸酯形式。 1,3-甘油二酸酯异构体在急性，短期，亚慢性或慢性动物试验中不是重要的毒物。甘油二月桂酸酯在白化病兔子中是轻度的主要刺激物，但在豚鼠最大化试验中不是皮肤致敏剂。在Ames试验，中国仓鼠肺细胞或啮齿类动物骨髓微核试验中，二酰基甘油油没有遗传毒性。含有1.5％的甘油二月桂酸酯的眼影在单次伤害斑贴试验中不会引起皮肤刺激，但观察到对含有相同浓度粉底的轻度皮肤刺激反应。在48小时的闭塞贴片试验中，未指定浓度的甘油二山hen酸酯的商业混合物不会引起刺激或明显的皮肤耐受性。在最大化测试中，眼影和含有1.5％甘油二月桂酸酯的粉底液都不是皮肤敏化剂。在反复侮辱性闭塞性贴片试验中，在用50％w / w甘油二油酸酯测试的贴片中未引起敏化作用。乳酸棕榈酸甘油酯（50％w / v）在重复伤害斑贴试验中未引起皮肤刺激或过敏。在健康志愿者中，使用含1.0％甘油基罗辛酸酯的口红测试时，未诱导出光毒性或光致过敏性。两种二酰基甘油（1-油酰基-2-乙酰酰基-sn-甘油和1,2-二棕榈酰-sn-甘油）在体外正常人真皮成纤维细胞中的剂量不超过10微克，不会改变细胞增殖（通过DNA合成测定） /毫升。在没有引发的情况下，二硬脂酸甘油酯在抗肿瘤株的随机繁殖的小鼠中诱导了中等程度的增生反应，并且通过9,10-二甲基-1,2-苯并蒽（DMBA）引发，总细胞数增加了。观测到的。在甘油单酯研究中，将DMBA一次应用到皮肤上，然后每周两次使用5％甘油硬脂酸甘油酯，均未产生肿瘤，但在应用部位出现了轻微的表皮增生。甘油二油酸酯在体外诱导3-甲基胆甾烷引发的BALB / 3T3 A31-1-1克隆细胞中的转化。促肿瘤的给药方案包括每天两次向雌性小鼠多次应用10 mol的1,2-二酰基甘油（sn-1,2-二癸酰甘油），连续1周，导致蛋白激酶C降低60％以上（ PKC）活性和明显的表皮增生。每周两次应用10 micromol sn-1,2-十二烷酰甘油，持续1周可降低i

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号