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首页> 外文期刊>British journal of neurosurgery >Polymorphism of the heme oxygenase-1 gene and cerebral aneurysms.
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Polymorphism of the heme oxygenase-1 gene and cerebral aneurysms.

机译：血红素加氧酶-1基因的多态性和脑动脉瘤。

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摘要

Inflammation is thought to play an important role in intracranial aneurysm formation. Heme-oxygenase-1(HO-1) is a novel anti-inflammatory factor. A length polymorphic variant of the HO-1 gene promoter region, comprising (GT)n dinucleotide repeats, is associated with altered levels of gene transcription: long (= 36 GT) repeats are associated with decreased HO-1. We hypothesized that patients with aneurysmal subarachnoid haemorrhage were more likely to have long repeats than controls. Sixty-nine patients with aneurysms and 230 age-matched controls were genotyped, and allelic repeats were classed as <36 (short and medium repeats) and >36 (long repeats). Patients were more likely to have =36 repeats than controls (8 v. 4%, p = 0.037. Control patients without aneurysms were more likely to have short alleles. Thus, facilitated up-regulation of HO-1 may be a protective anti-inflammatory factor against the development of intracranial aneurysms, whilst a propensity to a more pro-inflammatory state may put individuals at risk. However, because of the relatively small sample size and modest statistical significance, the data must be interpreted with caution and the association needs to be confirmed in further samples.
机译：人们认为炎症在颅内动脉瘤形成中起重要作用。血红素加氧酶-1（HO-1）是一种新型的抗炎因子。 HO-1基因启动子区域的长度多态性变体，包括（GT）n二核苷酸重复序列，与基因转录水平的改变有关：长（= 36 GT）重复序列与HO-1减少有关。我们假设患有动脉瘤的蛛网膜下腔出血的患者与对照组相比，重复时间更长。对69例动脉瘤患者和230名年龄匹配的对照进行基因分型，等位基因重复分类为<36（短和中等重复）和> 36（长重复）。患者比对照组更有可能重复= 36次（8 v。4％，p = 0.037。没有动脉瘤的对照患者更可能具有短等位基因，因此，促进HO-1的上调可能是一种保护性抗炎症因子会抑制颅内动脉瘤的发展，而倾向于更炎性的状态可能会使个体处于危险之中，但是，由于样本量相对较小且统计意义不大，因此必须谨慎解释数据，并且需要关联有待进一步确认。

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