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首页> 外文期刊>British journal of neurosurgery >1.5T versus 3T MRI for targeting subthalamic nucleus for deep brain stimulation
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1.5T versus 3T MRI for targeting subthalamic nucleus for deep brain stimulation

机译：1.5T与3T MRI靶向丘脑下核进行深部脑刺激

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Background. Accurate stereotactic placement of the electrode into the subthalamic nucleus (STN) is imperative to the therapeutic efficacy of deep brain stimulation (DBS). However, it is not always possible to directly visualize the very small STN using 1.5T MR imaging. Objective. To evaluate whether 3T MR imaging can provide better identification of the STN and clinical outcome than 1.5T MR imaging. Methods. Thirty-nine patients with advanced Parkinson's disease underwent 1.5T (n = 16) or 3T (n = 23) fast spin echo T2-weighted (FSE-T2WI) MR imaging for targeting the STN. A semi-quantitative 3-point scoring system was proposed to rank the clearness of STN contour: Score "0" if non-visible; Score "1" if visible but with blurred margin; and "2" if visible with clear margin. The unified Parkinson's disease rating scale (UPDRS) was also compared before operation and post-operation. Results. The STN score was 2 in all the patients of the 3T group, whereas it was relatively blurred (mean score, 1.19) in the 1.5T group (P < 0.001). The number of microelectrode trajectories (1.2 versus 1.5; P < 0.05) was lower in the 3T group; consequently, the operative time was also less (P < 0.05) as compared with that in the 1.5T group. The outcome of UPDRS motor examination showed no significant difference in two groups. Conclusion. 3T MR imaging is a reliable and more accurate method for direct targeting of the STN for DBS surgery. However, the technique of high-sequence MR imaging may not influence the clinical outcome significantly.
机译：背景。将电极正确地立体定向放置到丘脑底核内（STN）对于深部脑刺激（DBS）的治疗功效至关重要。但是，并非总是可以使用1.5T MR成像直接可视化非常小的STN。目的。为了评估3T MR成像是否可以比1.5T MR成像更好地识别STN和临床结果。方法。三十九例晚期帕金森病患者接受了1.5T（n = 16）或3T（n = 23）的快速自旋回波T2加权（FSE-T2WI）MR成像，以STN为靶标。提出了一种半定量的三点评分系统来对STN轮廓的清晰度进行排序：如果不可见，则得分为“ 0”;如果不可见，则得分为“ 0”。如果可见，但边缘模糊，则打“ 1”分;如果可见且边距清晰，则为“ 2”。还比较了术前和术后的统一帕金森氏病评分量表（UPDRS）。结果。 3T组的所有患者的STN评分均为2，而1.5T组的STN评分相对模糊（平均评分为1.19）（P <0.001）。 3T组的微电极轨迹数量较少（1.2对1.5; P <0.05）。因此，与1.5T组相比，手术时间也更少（P <0.05）。 UPDRS运动检查的结果在两组中没有显着差异。结论。 3T MR成像是直接靶向STN进行DBS手术的可靠且更准确的方法。但是，高序列MR成像技术可能不会显着影响临床结果。

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