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首页> 外文期刊>British journal of neurosurgery >Long-term follow-up of bilateral subthalamic nucleus stimulation in Chinese Parkinson's disease patients
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Long-term follow-up of bilateral subthalamic nucleus stimulation in Chinese Parkinson's disease patients

机译：中国帕金森氏病患者双侧丘脑下核刺激的长期随访

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Background and purpose. The long-term benefits of deep bilateral brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with advanced Parkinson's disease (PD) are less well described, especially in Chinese cohorts. Here, we present a large group of Chinese PD patients treated with bilateral STN DBS. Methods. Between 2003 and 2010,195 consecutive PD patients received implants at the Xuanwu Hospital affiliated to the Capital Medical University in Beijing (China) for bilateral STN DBS. The mean age at implantation was 58.2 ± 10.0 years, and they had a 5- to 15-year history of PD (mean: 6.8 years). Patients were assessed with the Unified Parkinson's Disease Rating Scale (UPDRS) at 1,3, and 5 years, both on and off medication. Results. Except for speech, patients 'off-medication motor function scores at 5 years improved by 60.3% (P < 0.001) and those for activities of daily living improved by 54.2% (P < 0.001). With the exception of dyskinesia, on-medication motor function scores did not improve 1 year after surgery. On-medication akinesia, speech, postural stability, and freezing of gait worsened between years 1 and 5 (all P < 0.001). At 5 years, dopaminergic treatment dose and the duration and severity of levodopa-induced dyskinesia were reduced compared with baseline (all P < 0.001). There was one death associated with surgery to implant the STN DBS. Conclusions. PD patients who were treated with bilateral STN DBS exhibited marked motor function improvements over long-term follow-up while off medication and in dyskinesia while on medication.
机译：背景和目的。晚期帕金森氏病（PD）患者的丘脑底核（STN）的深部双侧脑刺激（DBS）的长期益处并未得到很好的描述，尤其是在中国人群中。在这里，我们介绍了一大批接受双侧STN DBS治疗的中国PD患者。方法。在2003年至2010年之间，连续195例PD患者在北京（中国）首都医科大学附属宣武医院接受了双侧STN DBS植入。植入时的平均年龄为58.2±10.0岁，他们有5至15年的PD病史（平均：6.8年）。分别在1,3和5年时用统一帕金森氏病病情评估量表（UPDRS）对患者进行评估，包括药物的开和关。结果。除言语外，患者在5年的药物外运动功能评分改善了60.3％（P <0.001），而日常生活活动能力改善了54.2％（P <0.001）。除运动障碍外，手术后1年服药后运动功能评分未改善。在治疗的第1至5年间，服药期间的运动障碍，言语，姿势稳定性和步态冻结情况恶化（所有P <0.001）。与基线相比，在5年时，多巴胺能治疗剂量以及左旋多巴诱发的运动障碍的持续时间和严重程度均降低（所有P <0.001）。植入STN DBS的手术导致一例死亡。结论在长期停药期间和服药后的运动障碍患者中，接受双侧STN DBS治疗的PD患者的运动功能明显改善。

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