...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Investigative ophthalmology & visual science >Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome.
【24h】

Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome.

机译：CXCL9，-10，-11和CXCR3在干眼症患者的泪膜和眼表中的表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: To investigate the expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. METHODS: Thirty-three patients with dry eye (16 with and 17 without Sjogren's syndrome) and 15 control subjects were recruited. The concentrations of CXCL9, -10, and -11 in tears were measured with enzyme-linked immunosorbent assays. The correlation between chemokine levels and tear film and ocular surface parameters was analyzed. The expression of CXCL9, -10, -11, and CXCR3 in the conjunctiva was evaluated by using immunohistochemistry. Flow cytometry was performed to count CXCR3(+) cells and CXCR3(+)CD4(+) cells in the conjunctiva. RESULTS: The concentrations of CXCL9, -10, and -11 were 1,148 +/- 1,088, 24,338 +/- 8,706, and 853 +/- 334 pg/mL, in the patients with dry eye, and 272 +/- 269 (P = 0.01), 18,149 +/- 5,266 (P = 0.02), and 486 +/- 175 (P < 0.01) pg/mL in the control subjects, respectively. The concentrations significantly increased in tears of the patients with Sjogren's syndrome compared with those of the patients with non-Sjogren's dry eye (P < 0.05). CXCL10 levels correlated significantly with basal tear secretion, and CXCL11 levels correlated significantly with basal tear secretion, tear clearance rate, keratoepitheliopathy score, and goblet cell density (P < 0.05). Staining for CXCL9, -10, -11, and CXCR3 increased in patients with dry eye, especially in the patients with Sjogren's syndrome. Flow cytometry demonstrated an increased number of CXCR3(+) and CXCR3(+)CD4(+) cells in all the patients with dry eye. CONCLUSIONS: Expression of CXCL9, -10, -11, and CXCR3 increased in the tear film and ocular surface of patients with dry eye syndrome, especially in those with Sjogren's syndrome. CXCL11 levels correlated significantly with various tear film and ocular surface parameters. (ClinicalTrials.gov number, NCT00991679.).
机译：目的：探讨CXCL9，-10，-11和CXCR3在干眼症患者泪膜和眼表中的表达。方法：招募了33例干眼患者（16例有干燥综合征的患者和17例无干燥综合征的患者）和15例对照组。用酶联免疫吸附测定法测量眼泪中CXCL9，-10和-11的浓度。分析了趋化因子水平与泪膜和眼表参数之间的相关性。通过免疫组织化学评估CXCL9，-10，-11和CXCR3在结膜中的表达。进行流式细胞术以计数结膜中的CXCR3（+）细胞和CXCR3（+）CD4（+）细胞。结果：干眼患者的CXCL9，-10和-11的浓度分别为1,148 +/- 1,088、24,338 +/- 8,706和853 +/- 334 pg / mL，而272 +/- 269（ P = 0.01），对照组的18,149 +/- 5,266（P = 0.02）和486 +/- 175（P <0.01）pg / mL。与非干燥综合征干眼患者相比，干燥综合征患者眼泪中的浓度显着增加（P <0.05）。 CXCL10水平与基础泪液分泌显着相关，CXCL11水平与基础泪液分泌，泪液清除率，角膜上皮病评分和杯状细胞密度显着相关（P <0.05）。在干眼症患者中，特别是在干燥综合征患者中，对CXCL9，-10，-11和CXCR3的染色增加。流式细胞仪表明，在所有干眼患者中，CXCR3（+）和CXCR3（+）CD4（+）细胞数量均增加。结论：CXCL9，-10，-11和CXCR3在干眼症患者，尤其是干燥综合征患者的泪膜和眼表中表达增加。 CXCL11水平与各种泪膜和眼表参数显着相关。 （ClinicalTrials.gov编号，NCT00991679。）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号