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首页> 外文期刊>Investigative ophthalmology & visual science >Cirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis.
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Cirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis.

机译：Cirrus高清光学相干断层扫描与Stratus光学相干断层扫描相比，在青光眼的诊断中具有优势。

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PURPOSE: To compare the retinal nerve fiber layer (RNFL) evaluation using Cirrus optical coherence tomography (OCT) and Stratus OCT in glaucoma diagnosis. METHODS: One hundred thirty normal and 86 patients with glaucoma were included in this prospective study. The signal strengths of the OCTs were evaluated. The sensitivities and specificities of global RNFL average thickness were compared in the four quadrants and in each clock hour sector. Receiver operating characteristic (ROC) curves, areas under the ROC (AUC), and the likelihood ratio (LR) were plotted for RNFL thickness. Agreement between the OCTs was calculated by using the Bland-Altman method and kappa (kappa) coefficient. RESULTS: Twenty-three percent of all cases examined with Stratus OCT and 1.9% examined with Cirrus OCT had a signal strength below 6 (P = 0.01). In cases with signal strengths > or =6, the mean signal strength was higher with Cirrus OCT than with Stratus OCT (P = 0.01). The RNFL measurements by Cirrus were thicker than those of Stratus OCT (P < 0.05). The AUCs were 0.829 for Stratus and 0.837 for Cirrus OCT (P = 0.706) for global RNFL average. LRs were similar in both OCTs in global RNFL classification but varied in quadrants. The widths of the limits of agreement varied between 42.16 and 97.79 microm. There was almost perfect agreement (kappa = 0.82) in the average RNFL classification. CONCLUSIONS: Cirrus OCT has better scan quality than Stratus OCT, especially in glaucomatous eyes. In cases with good-quality scans, the sensitivity and specificity, and AUCs were similar. The best agreement was in the global average RNFL classification. The widths of limits of agreements exceed the limits of resolution of the OCTs.
机译：目的：比较使用Cirrus光学相干断层扫描（OCT）和Stratus OCT对青光眼的视网膜神经纤维层（RNFL）评估。方法：该前瞻性研究纳入了130例正常人和86例青光眼患者。评估了OCT的信号强度。在四个象限和每个时钟小时扇区中比较了全球RNFL平均厚度的敏感性和特异性。绘制了RNFL厚度的接收器工作特性（ROC）曲线，ROC下面积（AUC）和似然比（LR）。使用Bland-Altman方法和kappa（kappa）系数计算OCT之间的一致性。结果：Stratus OCT检查的所有病例中有23％，Cirrus OCT检查的所有病例中有1.9％的信号强度低于6（P = 0.01）。在信号强度大于或等于6的情况下，Cirrus OCT的平均信号强度高于Stratus OCT（P = 0.01）。 Cirrus的RNFL测量值比Stratus OCT的测量值厚（P <0.05）。对于全球RNFL平均值，Stratus的AUC为0.829，Cirrus OCT的AUC为0.837（P = 0.706）。在全球RNFL分类中，两个OCT中的LR相似，但象限中的象限不同。一致极限的宽度在42.16到97.79微米之间变化。 RNFL的平均分类几乎完全一致（kappa = 0.82）。结论：Cirrus OCT比Stratus OCT具有更好的扫描质量，尤其是在青光眼中。在高质量扫描的情况下，敏感性和特异性以及AUC相似。最好的协议是在全球平均RNFL分类中。协议限制的范围超出了OCT解决方案的限制。

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