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首页> 外文期刊>Investigative ophthalmology & visual science >Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage.
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Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage.

机译：在慢性压力诱发的视神经损伤大鼠模型中，眼压对视盘形貌，视网膜电图和轴突损失的影响。

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PURPOSE: To characterize the effect of intraocular pressure (IOP) on optic disc topography, retinal function, and axonal survival in a model of IOP-induced optic nerve damage in rat. METHODS: Hypertonic (1.75 M) saline was injected into an episcleral vein of one eye of 49 Brown Norway rats, with the fellow untreated eye serving as the control. During the 1 to 3 months of follow-up, IOP was measured twice weekly in conscious animals with a handheld tonometer, and changes in disc topography and retinal function were monitored with scanning laser tomography and electroretinography (ERG), respectively. Peak IOP elevation in the experimental eye compared with the fellow control eye (peak deltaIOP), integral of IOP elevation over time (deltaIOP integral), and days of IOP elevation were calculated. Axon counts were obtained from electron micrographs of the sectioned optic nerves. RESULTS: Progressive cupping was found in 9 (56.3%) of 16 eyes with peak deltaIOP of more than 15 mm Hg and in none of 21 eyes with peak deltaIOP less than 15 mm Hg. A strong correlation between deltaIOP integral and progressive cupping was also found, but not with days of IOP elevation. ERG abnormalities (limited to the b-wave) were found in 11 (64.7%) of 17 eyes with peak deltaIOP of more than 15 mm Hg and in 2 (8.7%) of 23 eyes with peak deltaIOP of less than 15 mm Hg. Neither of the other IOP parameters was predictive of ERG damage. The proportion of surviving axons was negatively correlated to both deltaIOP and deltaIOP integral (P
机译：目的：在眼压引起的大鼠视神经损伤模型中表征眼压（IOP）对视盘形貌，视网膜功能和轴突存活的影响。方法：将高渗盐水（1.75 M）注射到49只褐挪威大鼠的一只眼睛的巩膜静脉中，另一只未治疗的眼睛作为对照。在1至3个月的随访期间，使用手持式眼压计每周两次对清醒动物进行IOP测量，并分别通过扫描激光断层扫描和视网膜电图（ERG）监测椎间盘的形态和视网膜功能的变化。计算了与另一只对照眼相比，实验眼的峰值IOP升高（峰值deltaIOP），IOP随时间的升高积分（deltaIOP积分）和IOP升高的天数。轴突计数从切片视神经的电子显微照片中获得。结果：在16眼的峰值deltaIOP大于15 mm Hg的眼睛中有9眼（56.3％）发现了渐进拔罐，而在峰值ΔIOP小于15 mm Hg的21眼中没有发现。还发现deltaIOP积分与渐进性拔罐之间有很强的相关性，但与IOP升高的天数没有关系。在峰值deltaIOP大于15 mm Hg的17眼中有11眼（64.7％）发现了ERG异常（仅限于b波），在峰值deltaIOP小于15 mm Hg的23眼中有2例（8.7％）发现了ERG异常。其他IOP参数均不能预测ERG损害。存活的轴突的比例与deltaIOP和deltaIOP积分均呈负相关（P <或= 0.001）。渐进性拔罐仅在轴突损失超过55％时才明显。同样，ERG结果大部分维持在中低轴突丢失的正常范围内，但明显异常，轴突丢失超过70％。结论：该模型的结构和功能变化与峰值δIOP最佳相关，与IOP升高持续时间无关，这表明存在与IOP相关的损伤阈值。

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