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首页> 外文期刊>Investigative ophthalmology & visual science >Tumor-infiltrating macrophages (CD68(+) cells) and prognosis in malignant uveal melanoma.
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Tumor-infiltrating macrophages (CD68(+) cells) and prognosis in malignant uveal melanoma.

机译：肿瘤浸润性巨噬细胞（CD68（+）细胞）和恶性葡萄膜黑色素瘤的预后。

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PURPOSE: To investigate the hypothesis that tumor-infiltrating macrophages contribute to prognosis of uveal melanoma and to study their association with tumor characteristics, especially microvessels. METHODS: This was a retrospective, population-based cohort study of 167 consecutive patients who had had an eye with choroidal and ciliary body melanoma removed between 1972 and 1981. Macrophages were identified with mAb PG-M1 to the CD68 epitope, and their number and morphologic type were recorded. Kaplan-Meier and Cox regression analyses of melanoma-specific survival were performed. RESULTS: CD68-positive macrophages could be assessed in 139 (83%) of the 167 melanomas. Their number was moderate to high in 115 (83%) of the 139 tumors, and their morphology ranged from dendritic to round. A high number of macrophages was associated with presence of epithelioid cells (P = 0.025), heavy pigmentation (P = 0.001), and high microvascular density (P = 0.001). The 10-year melanoma-specific mortality rate increased with higher numbers of macrophages (0.10 for low versus 0.57 for high numbers, P = 0.0012). The morphologic type of infiltrating macrophages was not associated with mortality. The number of macrophages was modeled by stratification, which significantly improved a Cox regression model (P < 0.001). Adjusting for the other independent indicators of metastatic death 10-year melanoma-specific mortality was 0.17 for low versus 0.45 for high numbers of macrophages. CONCLUSIONS: The number of tumor-infiltrating CD68-positive macrophages contributes to prognosis and associates with cell type and microvascular density, which merits a further analysis of the biological role of these cells in uveal melanoma.
机译：目的：探讨肿瘤浸润性巨噬细胞有助于葡萄膜黑色素瘤预后的假说，并研究其与肿瘤特征，尤其是微血管的关系。方法：这是一项基于人群的回顾性队列研究，研究对象是1972年至1981年间连续167例脉络膜和睫状体黑色素瘤摘除的患者。巨噬细胞由CD68表位的mAb PG-M1鉴定，其数量和记录形态学类型。进行了黑素瘤特异性生存的Kaplan-Meier和Cox回归分析。结果：167例黑色素瘤中有139例（83％）可评估CD68阳性巨噬细胞。在139例肿瘤中，有115例（占83％）的肿瘤数量中等至高，且形态从树突状到圆形不等。大量巨噬细胞与上皮样细胞的存在（P = 0.025），色素沉着（P = 0.001）和高微血管密度（P = 0.001）有关。 10年黑素瘤特异性死亡率随着巨噬细胞数量的增加而增加（低数为0.10，高数为0.57，P = 0.0012）。浸润性巨噬细胞的形态学类型与死亡率无关。通过分层对巨噬细胞的数量进行建模，这显着改善了Cox回归模型（P <0.001）。调整其他独立的转移性死亡指标，十年期黑色素瘤特异性死亡率低（0.17％），高巨噬细胞（0.45％）。结论：肿瘤浸润性CD68阳性巨噬细胞的数量有助于预后，并与细胞类型和微血管密度有关，这需要进一步分析这些细胞在葡萄膜黑色素瘤中的生物学作用。

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